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TranscriptomicsViral Expression and Molecular Profiling in Liver Tissue versus Microdissected Hepatocytes in Hepatitis B Virus - Associated Hepatocellular Carcinoma
The molecular mechanisms whereby hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) remain elusive. We used genomic and molecular techniques to investigate host-virus interactions by mapping the entire liver of patients with HCC. We compared the gene signature of whole liver tissue (WLT)...
ORGANISM(S): Homo sapiens 
2014-12-22 | E-GEOD-55092 | biostudies-arrayexpress
TranscriptomicsIdentification of microRNAs specifically expressed in HCV-associated hepatocellular carcinoma
Background: Several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC) but the data are not univocal. Methods: We performed a microarray study of miRNAs in hepatitis C virus (HCV)-associated HCC and other liver diseases and healthy conditions. Results and Concl...
ORGANISM(S): Homo sapiens 
2013-02-20 | E-GEOD-40744 | biostudies-arrayexpress
TranscriptomicsInhibition of Interleukin-6 (IL-6) Signaling and Tumor Growth by a Human Neutralizing Anti-IL-6 Antibody with a Prolonged Half-Life
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a major role in responding to injury or infection as well as immune response, inflammation, and hematopoiesis. High levels of circulating IL-6 are observed in many tumor types and are associated with poor outcomes. We show that knockdown of...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-62941 | biostudies-arrayexpress
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