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Gene expression differences between TILs that are reactive to tumor cells and TILs that are not reactive
RNA-seq of T in PBMC and TILs
Transcriptomic profile of Traf6-deficient CD8+ TILs
RNA-sequencing of melanoma-derived tumor-infiltrating lymphocytes (TILs)
Gene expression signature of ex vivo expanded TILs for 14 day
Clinical significance of tumor-infiltrating lymphocytes (TILs) was demonstrated in many tumor types. In the clinical trials, immune check point inhibitors showed significant clinical efficacy in some tumor types with high mutation burden such as melanoma, bladder cancer, and smoking-induced lung can...
ORGANISM(S): Homo sapiens 
2025-06-30 | GSE252437 | GEO
CD8+ T cells isolated from HCC tissue were divided into three groups: PD1-TIM3- CD8+ TILs, exhibiting full effector function; PD1-intTIM3+ CD8+ TILs, exhibiting partial exhaustion; and PD1-hiTIM3+ CD8+ TILs, exhibiting severe exhaustion, as reflected by the differences in their ability to produce ef...
ORGANISM(S): Homo sapiens 
Adoptive T-cell Therapy (ACT) involves using tumor-infiltrating lymphocytes (TIL) isolated from metastatic melanoma and expanding them ex vivo prior to infusion into lympho-depleted patients. This is one of the most promising approaches to treat metastatic melanoma, with the rates of clinical respo...
ORGANISM(S): Homo sapiens 
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