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MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
UnknownSurfactant Protein-D Is Essential for Immunity to Helminth Infection.
Not available
S-EPMC4763345 | biostudies-literature
TranscriptomicsTranscription profiling of erB2-dependent response over time to EGF and HRG stimulation of human mammary luminal epithelial cells
Our aim was to identify time-dependent changes in gene expression associated with Epidermal Growth Factor (EGF) and Hergulin B1 (HRG) stimulation of normal human mammary luminal epithelial cells (HB4a) and a derivative cell line (C3.6)overexpressing the receptor tyrosine kinase ErbB2/HER2. Serum-sta...
ORGANISM(S): Homo sapiens 
2006-08-15 | E-TABM-106 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of Chlamydia trachomatis Serovar D genes under different in-vitro hormonal conditions
In this project we examined in-vitro effect of female sex hormones, estradiol and progesterone at average physiological concentration level on Chlamydia trachomatis gene expression level. Regulation of chlamydial gene expression by the female sex hormones oestradiol and progesterone was examined. A ...
ORGANISM(S): Chlamydia trachomatis 
2010-09-16 | E-GEOD-24119 | biostudies-arrayexpress
UnknownHigh-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial.
Not available
S-EPMC4176755 | biostudies-literature
UnknownAGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.
Not available
S-EPMC3541941 | biostudies-literature
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
TranscriptomicsProgesterone activates multiple innate immune pathways in Chlamydia trachomatis-infected endocervical cells
In this project we examined the in-vitro effect of female sex hormones (estradiol and progesterone at average physiological concentrations) during a infection mediated by Chlamydia trachomatis serovar D, on the gene expression of human endometrial cell line ECC-1 The effects of the female sex hormon...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-31149 | biostudies-arrayexpress
UnknownTBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer.
Not available
S-EPMC4451173 | biostudies-literature
UnknownChanges in Endogenous and Exogenous Koala Retrovirus Subtype Expression over Time Reflect Koala Health Outcomes.
Not available
S-EPMC6714790 | biostudies-literature
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