Sort   by:  
 Page size 
UnknownEmerging Treatments for Retinitis Pigmentosa: Genes and stem cells, as well as new electronic and medical therapies, are gaining ground.
Not available
S-EPMC4617761 | biostudies-literature
ProteomicsDesign and Development of DNA Damage Chemical Inducers of Proximity (DD-CIP) for Targeted Cancer Therapy
Many chemotherapies are effective against cancers that display high levels of genome instability by disrupting or overwhelming the DNA damage response to induce cell death. PARP inhibitors (PARPi) exploit this vulnerability by stalling DNA repair particularly in homologous recombination (HR)-deficie...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-12-06 | MSV000100135 | MassIVE
TranscriptomicsInteractions of aCPs with Cytosine-rich Polypyrimidine Tracts Enhance Splicing of Cassette Exons
Alternative splicing comprises a robust generator of mammalian transcriptome complexity. Splice site specification and activity are controlled by interactions of cis-acting determinants on a transcript with specific RNA binding proteins. A major subset of these interactions comprises interactions lo...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-71569 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of mouse hematopoietic stem cells infect ed with shPRox1 or shLuciferase
Global gene expression profiles of shProx1 vs. shLuciferase infected mouse hematopoietic stem cells.
ORGANISM(S): Mus musculus 
2010-08-01 | E-MTAB-290 | biostudies-arrayexpress
GenomicsDevelopmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos (MRE-seq)
DNA methylation undergoes dynamic changes during development and cell differentiation. Recent genome-wide studies discovered that tissue-specific differentially methylated regions (DMRs) often overlap tissue-specific distal cis-regulatory elements. However, developmental DNA methylation dynamics of ...
ORGANISM(S): Danio rerio 
2015-02-13 | E-GEOD-52704 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of immortalized N/TERT keratinocytes stimulated with IFNγ
Inflammasomes are multicomplex proteins which drive pro-inflammatory cytokine responses and pyroptosis in innate immunity. Of which, the NLRP3 inflammasome is the most extensively studied, especially in myeloid immune cells such as macrophages. Conversely, the regulation of NLRP3 in non-immune cell ...
ORGANISM(S): Homo sapiens 
2025-10-30 | E-MTAB-15754 | biostudies-arrayexpress
GenomicsDevelopmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos (MeDIP-seq)
DNA methylation undergoes dynamic changes during development and cell differentiation. Recent genome-wide studies discovered that tissue-specific differentially methylated regions (DMRs) often overlap tissue-specific distal cis-regulatory elements. However, developmental DNA methylation dynamics of ...
ORGANISM(S): Danio rerio 
2015-02-13 | E-GEOD-52703 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CT116 cells and isogenic genetic knockouts rveals identity of the human cancer cell DNA hypermethylome
Altered gene expression is a hallmark of human cancers and arises in part through abnormal epigenetic regulation of gene transcription. The best characterized epigenetic alteration involves tumor suppressor gene inactivation via transcriptional repression associated with aberrant DNA hypermethylatio...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4763 | biostudies-arrayexpress
ProteomicsExtrarenal ?-klotho expression in human tissues
?-Klotho has emerged as a powerful regulator of the ageing process. To-date, the expression profile of ?-Klotho in human tissues is unknown and its existence in some human tissue types is subject to much controversy. Objective: This is the first study to characterize system-wide tissue expression of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080719 | MassIVE
TranscriptomicsUse of clinical chromosomal microarray in Chinese patients with autism spectrum disorder - implications of a copy number variation involving dpp10 (Perkin Elmer CGX)
Background Array-Comparative-Genomic-Hybridization (aCGH) is recommended as first-tier genetic test for children with autism spectrum disorder (ASD). However, result interpretation can be challenging as copy number variants (CNVs) in non-European ASD patients is not well studied. To address this lit...
ORGANISM(S): Homo sapiens 
2017-04-07 | E-MTAB-5672 | biostudies-arrayexpress
Sort   by:  
 Page size