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TranscriptomicsTranscription profiling of human Ewing sarcoma samples and EWS-FLI-1 inhibited Ewing sarcoma cell lines
The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced Ewing cel...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7007 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Ewing sarcoma samples
Expression profiling of Ewing sarcoma samples in the frame of the CIT program from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Ewing sarcoma a rare pediatric tumor characterized by EWSR1-ETS fusions, is predominantly observed in populations of European ancestry. A geno...
ORGANISM(S): Homo sapiens 
2012-02-11 | E-GEOD-34620 | biostudies-arrayexpress
TranscriptomicsA new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
The identification of subtype-specific translocations has revolutionized diagnostics of sarcoma and provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-34800 | biostudies-arrayexpress
TranscriptomicsTargeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo
Identification of druggable targets is a prerequisite for developing targeted therapies against Ewing sarcoma. We report the identification of Protein Kinase C Beta (PRKCB) as a protein specifically and highly expressed in Ewing sarcoma as compared to other pediatric cancers. Its transcriptional act...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-38392 | biostudies-arrayexpress
GenomicsEwing sarcoma - WGS - samples
Description not provided
EGAD00001001051 | EGA
GenomicsPCGP EWS WGS - samples
DATA FILES FOR SJEWS-WGS
EGAD00001001020 | EGA
GenomicsTargeting the DNA Repair Pathway in Ewing Sarcoma
Ewing’s Sarcoma is a bone and soft tissue tumor that primarily affects adolescents and young adults. With current therapies, 70% of patients with localized disease survive but survival for metastatic and recurrent disease is poor. Whole genome sequencing of 19 Ewing’s Sarcoma tumors showed that STAG...
EGAS00001000839 | EGA
GenomicsGenomic landscape of Ewing sarcoma (ICGC project)
The Ewing sarcoma project aims to sequence 100 complete genomes of cells of patients suffering from this disease. It is an initiative of great projection, since this is the second most common bone tumor in children and teenagers. The goal of the project is to establish the catalogue of somatic mutat...
EGAS00001000855 | EGA
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