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ProteomicsIdentification of Isopeptides Between Human Tissue Transglutaminase and Wheat, Rye, and Barley Gluten Peptides
Celiac disease (CD) is a chronic immune-mediated enteropathy of the small intestine, which is triggered by the ingestion of storage proteins (gluten) from wheat, rye, and barley in genetically predisposed individuals. Human tissue transglutaminase (TG2) plays a central role in the pathogenesis of CD...
ORGANISM(S): Homo Sapiens Triticum Aestivum Secale Cereale Hordeum Vulgare 
2020-08-27 | PXD017693 | panorama
ProteomicsComprehensive detection of isopeptides between human tissue transglutaminase and gluten peptides using a reciprocal proteomic approach
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of gluten in genetically predisposed individuals. Tissue transglutaminase (TG2) is a key factor in the pathogenesis of CD, because it catalyzes both the deamidation of specific glutamine residues and the ...
ORGANISM(S): Homo sapiens (Human) Triticum aestivum (Wheat) 
2019-09-27 | PXD014067 | Pride
Celiac disease  transglutaminase  isopeptides  gluten 
GenomicsTissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages
Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages
PRJNA918974 | ENA
TranscriptomicsTranscription profiling of sputum samples from individuals exercise-induced bronchoconstriction (EIB).
Asthma is a heterogeneous disease. Exercise-induced bronchoconstriction (EIB) is a distinct syndrome that occurs in 30-50% of asthmatics and is characterized by high levels of pro-inflammatory eicosanoids. We identified genes differentially expressed in the airways of asthmatics with EIB relative to...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-13785 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells
Treatment of acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA) results in terminal differentiation of leukemic cells toward neutrophil granulocytes. Administration of ATRA leads to massive changes in gene expression, including down-regulation of cell proliferation-related genes ...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress
ProteomicsTissue Transglutaminase 2 has higher affinity for relaxed than for stretched fibronectin fibers
Chemical cross-linking coupled to mass spectrometry was used to study the interaction between fibronectin (Fn; full-length or gelatin-binding domain fragment = Fn 45) with tissue transglutaminase 2 in oxidized and non-oxidized form. The complexes were cross-linked with disuccinimidyl suberate (DSS) ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-20 | PXD043976 | Pride
Chemical cross-linking  dss  pdh  dmtmm  structural proteomics  fibronectin Tissue transglutaminase 2 
TranscriptomicsTissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages
To elucidate the reason why the tissue transglutaminase (TG2) knockdown and inactivation suppressed M2 macrophage polarization, we explored genes whose expression was regulated by TG2 activity and investigated the molecular mechanism underlying this.
ORGANISM(S): Homo sapiens 
2023-03-03 | GSE222284 | GEO
UnknownIdentification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase.
Not available
S-EPMC2368783 | biostudies-literature
ProteomicsGluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme digests of gluten treated with the deamidating en...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080779 | MassIVE
TranscriptomicsTranscription profiling of monkey model of neuroAIDS reveals induction of pathogenic sets of genes in macrophages and neurons
The etiology of the central nervous system (CNS) alterations after human immunodeficiency virus (HIV) infection, such as dementia and encephalitis, remains unknown. We have used microarray analysis in a monkey model of neuroAIDS to identify 98 genes, many previously unrecognized in lentiviral CNS pa...
ORGANISM(S): Macaca mulatta 
2008-06-12 | E-GEOD-2377 | biostudies-arrayexpress
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