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ProteomicsGlobal proteome and phosphoproteome alterations in 3rd generation EGFR TKI resistance reveal drug targets to circumvent resistance
Lung cancer continues to be the leading cause of cancer mortality worldwide. The treatment of lung cancer patients harboring mutant EGFR with orally administered EGFR TKIs has been a paradigm shift. Osimertinib and rociletinib are two 3rd generation irreversible EGFR TKIs targeting the EGFR T790M mu...
ORGANISM(S): Homo sapiens (Human) 
2021-03-11 | PXD020108 | Pride
Resistance mechanism Lung adenocarcinoma 3rd generation egfr tki 
TranscriptomicsGene expression changes during resistance toward vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) therapy in renal cell carcinoma (RCC)
This study was performed to understand the gene expression changes that accompany treatment of renal cell carcinoma (RCC) with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) therapy. Human RCC cell lines were implanted into the flanks of nude beige mice, allowed...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-64052 | biostudies-arrayexpress
GenomicsTFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma
TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma
PRJNA1160153 | ENA
TranscriptomicsMicroarray expression profile of long noncoding RNAs in EGFR-TKI resistance of lung adenocarcinoma
Lung adenocarcinoma cells harboring epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs). Prolonged cancer treatment will induce the development of acquired resistance to EGFR TKI. To gain insight into the molecular mechanisms of EGFR-TKIs resista...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-74575 | biostudies-arrayexpress
ProteomicsTKI-resistant T790M EGFR Mutation Rewired EGFR Translocation Routes through Switching Interactome in Non-Small Cell Lung Cancer
Epidermal growth factor receptor (EGFR) harboring active mutations, Del19 and L858R, are most common oncogenic mutations in in non-small cell lung cancer (NSCLC) patients. The preferred treatment at first line is tyrosine kinase inhibitor (TKI) administration while the TKI-resistance usually develop...
ORGANISM(S): Homo Sapiens (human) 
2023-05-31 | PXD034228 | JPOST Repository
GenomicsA Single-cell Atlas of Progressive TKI Resistance in Chronic Myeloid Leukemia
High-dimensional scRNA seq and CyTOF were used to identify features predictive of treatment outcome at diagnosis. An optimal TKI response was characterised by erythroid lineage skewing of the CD34+ HSPC compartment. While TKI-resistant CP was reminiscent of a BC-like state, where HSPCs were enriche...
EGAS00001005509 | EGA
ProteomicsResearch on the mechanism by which cancer-associated fibroblasts (CAFs) promote EGFR-TKI resistance in non-small cell lung cancer (NSCLC) via secretory proteins
Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) remains a major clinical challenge in the targeted therapy of non-small cell lung cancer (NSCLC), yet its underlying mechanisms are poorly understood. The tumor microenvironment (TME), which provides a supportive n...
ORGANISM(S): Homo Sapiens 
2025-05-26 | PXD064318 |
GenomicsTranscriptome profiling to determine molecular mechanisms of acquired EGFR TKI resistance
Transcriptome profiling to determine molecular mechanisms of acquired EGFR TKI resistance
PRJNA497901 | ENA
GenomicsAn East-Asian polymorphism underlies BCR-ABL mutation-independent resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia
We used massively parallel DNA sequencing of paired-end ditags (DNA-PET) to identify structural genetic factors associated with disease progression and drug-resistance in representative samples from four CML patients and one CML cell line. The functional consequences of our genetic findings were ev...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-28303 | biostudies-arrayexpress
TranscriptomicsEWS TC-71 cell lines: IGF-1R resistant
Ewing's Sarcoma cell lines were made resistant to different IGF-1R drugs to investigate mechanisms and pathways modulated by the resistance. EWS TC-71 cell line was exposed to increasing concentration to three different anti-IGF-1R drugs (HAb AVE1642, TKI NVP-AEW541, HAb CP-751,871, cell lines name...
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-34027 | biostudies-arrayexpress
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