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TranscriptomicsCell intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses
Endosomal Toll-like receptors (TLRs) play an important role in the etiology of systemic autoimmune diseases such as SLE, where DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways, respectively. Nevertheless, TLR9-deficient autoimmune prone mic...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-58756 | biostudies-arrayexpress
TranscriptomicsTLR7 gene duplication accelerates autoimmunity and promotes nucleolar-specific B cells
Systemic autoimmune diseases such as lupus and scleroderma are characterized by the loss of tolerance to nuclear antigens, but the mechanisms by which specific autoantibodies are selected are unclear. Here we report that B cells containing the Y-linked autoimmune accelerator (Yaa) locus are intrins...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-4445 | biostudies-arrayexpress
TranscriptomicsTreatment of human monocytes with TLR7 or TLR8 agonists
Goal was to detect differences in response to TLR7 versus TLR8 agonists in human monocytes from healthy donors 3 deidentified donors from the Red Cross, monocytes from each donor incubated overnight with either vehicle, TLR7 agonist or TLR8 agonist
ORGANISM(S): Homo sapiens 
2014-12-24 | E-GEOD-64480 | biostudies-arrayexpress
TranscriptomicsGene profiling in the colon after depletion and activation of TLR3 and TLR7 signals
TLR3 and TLR7 are critical recognition receptor which reacts with viruses. TLR3 and TLR7 contribute to many immunological pathway. Especially, TLR3 and TLR7 are clearly involved in the regulation of innate immunity in the gut. To identify the downstream target of TLR 3 and TLR7 in the IBD, we carrie...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-79241 | biostudies-arrayexpress
TranscriptomicsDC populations incubated with rAd5, rAd28, rAd35, TLR7/8-ligand, or unexposed
Recombinant adenovirus vectors (rAds) are being investigated as vaccine delivery vehicles in pre-clinical and clinical studies. rAds constructed from different serotypes differ in receptor usage, tropism, and ability to activate cells, aspects of which likely contribute to their different immunogeni...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-37128 | biostudies-arrayexpress
GenomicsTLR7 variants in human lupus patients
While circumstantial evidence supports enhanced TLR7 signaling as a mechanism of human systemic autoimmune disease, we have lacked the proof afforded by lupus-causing TLR7 gene variants. Here we undertook a whole exome sequencing (WES) approach to identify novel TLR7 variants in human lupus patients...
EGAS00001005965 | EGA
TranscriptomicsBCR repertoire analysis by Next-generation sequencing of lymphocytes harvested from mice vaccinated with liposomal TLR4 and TLR7 agonists
BALB/c mice were vaccinated with inactivated influenza A virus adjuvanted with liposomal TLR4 (2B182C) and TLR7 agonists (2B182C) on days 0 and 21. To examine whether the liposomal combined adjuvant increase BCR diversity, lymphocytes in the draining lymph nodes harvested on day 28 were analyzed usi...
ORGANISM(S): Mus musculus 
2021-03-01 | E-MTAB-8870 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells in vitro from CIS patients after Interferon beta-1a treatment
IFNβ, an effective therapy against relapsing-remitting (RR) multiple sclerosis (MS) is naturally secreted during the innate immune response against viral pathogens. The objective of this study was to characterize the immunomodulatory mechanisms of IFNβ targeting innate immune response and their effe...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-14386 | biostudies-arrayexpress
GenomicsUNC93B1 variants underlie TLR7-dependent autoimmunity
UNC93B1 variants underlie TLR7-dependent autoimmunity
PRJNA1052694 | ENA
TranscriptomicsTLR3, TLR7, and TLR9 stimulation in murine dorsal root ganglion neurons
TLR3, TLR7, and TLR9 stimulation induces many mouse inflammatory and autoimmune cytokines or immune receptors DRGN were cultures 5 days prior to a 16 hour stimulation - Three separate studies were analyzed for inflammatory response
ORGANISM(S): Mus musculus 
2011-03-02 | E-GEOD-27579 | biostudies-arrayexpress
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