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MetabolomicsSex differences modulate the serum metabolome profiles in Parkinson’s disease patients harbouring pathogenic mutations in GBA1, LRRK2, TMEM175, PARK2, PINK1, and PARK7 genes

Background: Sex and genetic background have an impact on Parkinson’s disease (PD) insurgence, but the comprehension of how these factors affect the circulating profile of PD patients is still an aim of study.

Objectives: In this study we aimed to investigate whether genetic background and ...

2026-06-26 | MTBLS12753 | MetaboLights
ProteomicsMulti-omics approach identifies a network of lipids and proteins associated to lysosomal and mitochondrial metabolism in Parkinson’s disease patients carrying mutations in TMEM175 gene.
Parkinson’s disease (PD) represents one of the most frequent neurodegenerative disorders for which clinically useful biomarkers remain to be identified and validated for early and more precise diagnosis or for differentiation of disease subtypes, which may require different treatments. In this study...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049990 | Pride
Parkinson disease Multi-omics Tmem175 mutation 
UnknownMechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
Not available
S-EPMC9636928 | biostudies-literature
MetabolomicsSex and subtype differences shape the blood metabolome profiles in Parkinson's disease.

Rationale: Sex and type of Parkinson's disease (PD) significantly influence onset age, clinical manifestations, treatment response, disease progression and life expectancy. However, the selective influence of idiopathic and familial forms of PD in disrupting blood metabolome profiles across gende...

2025-09-03 | MTBLS11187 | MetaboLights
UnknownIdentification of sixteen novel candidate genes for late onset Parkinson's disease.
Not available
S-EPMC8215754 | biostudies-literature
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