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Autophagy maintains cellular homeostasis by targeting damaged organelles, pathogens or misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated by the formation of autophagosomes, which can selectively enclose cargo via autophagy cargo receptors. A machinery of wel...
ORGANISM(S): Homo sapiens (Human) 
2018-08-20 | PXD010207 | Pride
TMEM41B is a pan-flavivirus host factor
TMEM41B: An Evolutionarily Conserved Nexus in Thermogenic Regulation
Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host factors required for flavivirus infection we performed full-genome loss of function CRISPR-Cas9 screens. Based on these ...
ORGANISM(S): Homo sapiens synthetic construct 
2020-11-24 | GSE162040 | GEO
TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness
Adipocyte-Specific TMEM41B Deficiency Enhances Bone Formation and Attenuates Osteoporosis via the YY1-Calreticulin Axis
Adipocyte-Specific TMEM41B Deficiency Enhances Bone Formation and Attenuates Osteoporosis via the YY1-Calreticulin Axis
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