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TranscriptomicsRadical prostatectomy specimens with and without TMPRSS2:ERG fusion from 139 patients with prostate in a Toronto cohort
Prostate tumors with the gene fusion TMPRSS2:ERG have been reported to have a significantly higher risk of recurrence compared with tumors lacking the fusion. Tumors from 139 patients who underwent radical prostatectomy were analyzed for the expression of 502 cancer-related genes to identify genes d...
ORGANISM(S): Homo sapiens 
2009-10-22 | E-GEOD-18655 | biostudies-arrayexpress
TranscriptomicsTMPRSS2-ERG fusion prostate cancer is a molecularly distinct estrogen-sensitive subclass of aggressive prostate cancer
Common epithelial cancers are believed to become more aggressive through the accumulation of multiple independent molecular events that lead to the deregulation of cell signaling. However, the discovery that the majority of prostate cancers harbor gene fusions of the 5'-untranslated region of androg...
ORGANISM(S): Homo sapiens 
2008-05-27 | E-GEOD-8402 | biostudies-arrayexpress
ProteomicsMapping Isoform Abundance and Interactome of the Endogenous TMPRSS2-ERG Fusion Protein by Orthogonal Immunoprecipitation-Mass Spectrometry Assays
Here, we developed immunoprecipitation-mass spectrometry assays for the measurement of a low-abundance T1E4 TMPRSS2-ERG fusion protein, its isoforms and its interactome in VCaP prostate cancer cells.
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD021236 | Pride
Tmprss2-erg fusion  vcap cells  erg protein isoforms  proteomics  mass spectrometry  selected reaction monitoring  erg interactome  cbaf complex  canonical swi/snf complex 
TranscriptomicsAn Integrated Network of Androgen Receptor and TMPRSS2-ERG Gene Fusion in Prostate Cancer Progression (II)
Androgen receptor (AR) is a transcription factor that plays a central role in the growth and development of the normal prostate and its malignant transformation. More recently, a majority of prostate cancers have been shown to harbor recurrent gene fusions of the androgen-regulated gene, TMPRSS2, t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-14092 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation.
Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large coho...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress
GenomicsAndrogen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion [microarray]
Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion [microarray]
PRJNA1221540 | ENA
TranscriptomicsTMPRSS2-ERG fusion prostate cancer is a molecularly distinct estrogen-sensitive subclass of aggressive prostate cancer
Common epithelial cancers are believed to become more aggressive through the accumulation of multiple independent molecular events that lead to the deregulation of cell signaling. However, the discovery that the majority of prostate cancers harbor gene fusions of the 5'-untranslated region of androg...
ORGANISM(S): Homo sapiens 
2008-05-28 | GSE8402 | GEO
GenomicsAndrogen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion [RNA-Seq]
Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion [RNA-Seq]
PRJNA1221534 | ENA
UnknownSignificance of the TMPRSS2:ERG gene fusion in prostate cancer.
Not available
S-EPMC5647090 | biostudies-literature
UnknownRole of the TMPRSS2-ERG gene fusion in prostate cancer.
Not available
S-EPMC2244693 | biostudies-literature
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