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ProteomicsTMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing
The development of the TMTpro-16plex series expanded the breadth of commercial isobaric tagging reagents by nearly 50% over classic TMT-11plex. In addition to the described 16plex reagents, the proline-based TMTpro molecule can accommodate two additional combinations of heavy carbon and nitrogen iso...
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD024275 | Pride
Real-time search Eclipse Byl-719 Pten Kin-193 18plex Tmtpro Mcf10a 
ProteomicsTAG-TMTpro, a hyperplexing quantitative approach for high-throughput proteomic studies
Isobaric labeling is the most widely used multiplexing quantitative approach in proteomic studies, enabling the comparison of up to 18 samples in a single MS analysis. Expanding the multiplexing capacity is of great necessity for high-throughput proteomic studies. Herein, we establish a novel TAG-TM...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-10-14 | PXD033711 | Pride
Proteomics Multiplexing quantitative approach Tmtpro labeling 
ProteomicsTMTpro: Design and initial evaluation of a novel Proline-based isobaric 16-plex Tandem Mass Tag reagent set
The design and synthesis of a novel proline-reporter-based isobaric Tandem Mass Tag 16 tag set (TMTpro) was carried out and the data uploaded here is a comparison of the performance of the new TMTpro tags with the current commercially available dimethylpiperidine-reporter-based TMT10/11 reagents. Da...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Rattus norvegicus (Rat) 
2019-11-25 | PXD014750 | Pride
Tmt Tmtpro 
ProteomicsTMTPro Complementary Ion Quantification Increase Plexing and Sensitivity for Accurate Multiplexed Proteomics at the MS2 level
The ability of the TMTPro isobaric labeling reagents to form complementary ions for accurate multiplexed proteomics at the MS2 level was investigated. Human and yeast peptides were labeled in distinct ratios to analyze the effect of interference on the quantification accuracy. A method, TMTProC, was...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-11 | PXD021661 | Pride
Complementary ion quantification Interference-free quantification Multiplexing Tmtpro 
ProteomicsSpectral Library Search for Improved TMTpro Labelled Peptide Assignment in Human Plasma Proteomics
Clinical biomarker discovery is often based on the analysis of human plasma samples. However, the high dynamic range and complexity of plasma pose significant challenges to mass spectrometry-based proteomics. Current methods for improving protein identifications require laborious pre-analytical samp...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042546 | Pride
Peptide identification  plasma proteomics  spectral library search  tmtpro 
UnknownTMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing.
Not available
S-EPMC8210943 | biostudies-literature
UnknownSuper Heavy TMTpro Labeling Reagent: An Alternative and Higher-Charge-State-Amenable Stable-Isotope-Labeled TMTpro Variant.
Not available
S-EPMC8210946 | biostudies-literature
ProteomicsOvercoming the detrimental O-acylation in TMTpro labeling improves the proteome depth and quantification precision.
The advent of TMTpro reagents expands the sample multiplexing capacity and enables quantification of up to 18 samples in a multiplexed manner. Similar to classic TMT reagents, TMTpro reagents contain a tertiary amine group in their mole-cules, which markedly enhances their reactivity toward hydroxyl...
ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae 
2023-12-19 | PXD043778 |
UnknownTMTpro Complementary Ion Quantification Increases Plexing and Sensitivity for Accurate Multiplexed Proteomics at the MS2 Level.
Not available
S-EPMC8330405 | biostudies-literature
UnknownTMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples.
Not available
S-EPMC7302421 | biostudies-literature
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