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UnknownDecoding gene regulatory circuitry underlying TNBC chemoresistance reveals biomarkers for therapy response and therapeutic targets.
Not available
S-EPMC10933292 | biostudies-literature
UnknownThe fate of chemoresistance in triple negative breast cancer (TNBC).
Not available
S-EPMC4661576 | biostudies-literature
UnknownCollagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance.
Not available
S-EPMC6203834 | biostudies-literature
UnknownCircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation.
Not available
S-EPMC11097450 | biostudies-literature
ProteomicsDrug Repurposing Identifies Proteasome Inhibitors as Antiproliferative Agents Counteracting Inflammation-Driven Chemoresistance in Triple-Negative Breast Cancer Organoids
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options, characterized by high relapse rates and poor survival outcomes due to chemoresistance. This study aimed to repurpose FDA-approved drugs to overcome chemoresistance in TNBC and elucidate their mechanisms of ...
ORGANISM(S): Homo Sapiens (human) 
2026-01-06 | PXD059504 | JPOST Repository
UnknownFZD5 contributes to TNBC proliferation, DNA damage repair and stemness.
Not available
S-EPMC7733599 | biostudies-literature
MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
TranscriptomicsUSP51-GRP78 axis promotes doxorubicin-resistance by regulating the activity of ABCB1 in TNBC
Background: Resistance to chemotherapy remains an obstacle for triple-negative breast cancer (TNBC) patients. The core components of the ubiquitin-proteasome system have been demonstrated to regulate chemoresistance of TNBC. As a novel DUB, ubiquitin-specific peptidase 51 (USP51) plays a pivotal rol...
ORGANISM(S): Homo sapiens 
2025-11-20 | GSE248421 | GEO
UnknownSingle-cell transcriptome sequencing reveals SPP1-CD44-mediated macrophage-tumor cell interactions drive chemoresistance in TNBC.
Not available
S-EPMC11233263 | biostudies-literature
GenomicsUSP51-GRP78 axis promotes doxorubicin-resistance by regulating the activity of ABCB1 in TNBC
USP51-GRP78 axis promotes doxorubicin-resistance by regulating the activity of ABCB1 in TNBC
PRJNA1043719 | ENA
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