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TranscriptomicsmiRNA array for LPS-activated tnc+/+ and tnc-/- macrophages
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defence, however their precise immunological role remains unclear. Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. We have show...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-41584 | biostudies-arrayexpress
TranscriptomicsRNA sequencing investigating the role of TNC in tumor progression using FVB TNC WT and TNC KO mice grafted with NT193 shC cells or NT193 shTNC cells
MMTV-NeuNT transgenic mouse model harbors an activated form of Neu (NeuNT). Mice develop stochastically multifocal mammary adenocarcinomas that metastasize to the lung (Muller et al., 1988). MMTV-NeuNT mouse model exhibits both intravascular and parenchymal metastasis which provides a good tool t...
ORGANISM(S): Mus musculus 
2021-03-25 | E-MTAB-10135 | biostudies-arrayexpress
GenomicsRNA sequencing investigating the role of TNC in tumor progression using FVB TNC WT and TNC KO mice grafted with NT193 shC cells or NT193 shTNC cells
RNA sequencing investigating the role of TNC in tumor progression using FVB TNC WT and TNC KO mice grafted with NT193 shC cells or NT193 shTNC cells
PRJEB43844 | ENA
TranscriptomicsTranscriptomic analysis investigating the role of TNC in tumor progression using the MMTV-NeuNT mouse model
MMTV-NeuNT transgenic mouse model harbors an activated form of Neu (NeuNT). Mice develop stochastically multifocal mammary adenocarcinomas that metastasize to the lung (Muller et al., 1988). MMTV-NeuNT mouse model exhibits both intravascular and parenchymal metastasis which provides a good tool t...
ORGANISM(S): Mus musculus 
2021-02-11 | E-MTAB-10149 | biostudies-arrayexpress
TranscriptomicsmiRNA array for LPS-activated tnc+/+ and tnc-/- macrophages
Endogenous molecules generated upon pathogen invasion or tissue damage serve as danger signals that activate host defence, however their precise immunological role remains unclear. Tenascin-C is an extracellular matrix glycoprotein that is specifically induced upon injury and infection. We have show...
ORGANISM(S): Rattus norvegicus Mus musculus 
2012-10-18 | GSE41584 | GEO
TranscriptomicsGene expression profiles of inoculated tumor cells in TNC-KO mice
Tenascin-C (TNC), a cancer-associated extracellular matrix glycoprotein, plays a pivotal role in tumor growth. To identify the genes regulated by TNC during tumor growth, we performed a tumor growth assay, DNA microarray analysis, and quantitative real-time PCR (qRT-PCR). Mouse mammary tumor cells w...
ORGANISM(S): Mus musculus 
2017-09-07 | GSE67896 | GEO
UnknownTNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice.
Not available
S-EPMC12604166 | biostudies-literature
UnknownThe role of TNC in atherosclerosis and drug development opportunities.
Not available
S-EPMC10750296 | biostudies-literature
UnknownTNC upregulation promotes glioma tumourigenesis through TDG-mediated active DNA demethylation.
Not available
S-EPMC11294444 | biostudies-literature
TranscriptomicsTenascin C prevents acute aortic dissection in mice
Acute aortic dissection (AAD) is one of the major aortic diseases that occurs without a preceding symptom and often results in sudden death. Despite the recent advances in cardiovascular medicine, AAD remains a serious problem because its molecular pathogenesis is largely unknown. In this paper, w...
ORGANISM(S): Mus musculus 
2015-03-27 | E-GEOD-36899 | biostudies-arrayexpress
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