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GenomicsChromatin maps of the Drosophila melanogaster TrxG protein Ash1 and FSH
Trithorax group (TrxG) proteins counteract Polycomb silencing by an as yet uncharacterized mechanism. A well-known member of the TrxG is the histone methyltransferase Absent, Small, or Homeotic discs 1 (ASH1). In Drosophila ASH1 is needed for the maintenance of Hox gene expression throughout develop...
ORGANISM(S): Drosophila melanogaster 
2013-06-30 | E-GEOD-30820 | biostudies-arrayexpress
ProteomicsGAIN domain cleavage of aGPCRs requires multiple domain-extrinsic factors coordinated by the 7TM region
The G protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain is a structurally conserved and tell-tale fold of class B2/adhesion GPCRs (aGPCRs). Self-cleavage of the GAIN domain is central for mechanobiological and signaling properties of aGPCRs. Biochemical analyses and atomistic de...
ORGANISM(S): Homo sapiens (Human) 
2025-10-01 | PXD056561 | Pride
Adhesion gpcr Photo-crosslinking Gain domain 
UnknownOvarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.
Not available
S-EPMC3458423 | biostudies-literature
UnknownCommon variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.
Not available
S-EPMC3733139 | biostudies-literature
UnknownCommon breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.
Not available
S-EPMC3326552 | biostudies-literature
UnknownIdentification of six new susceptibility loci for invasive epithelial ovarian cancer.
Not available
S-EPMC4445140 | biostudies-literature
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