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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
TranscriptomicsSpermidine Yeast Aging Array
Administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extends the lifespan of various model organisms including yeast, flies and worms. In ageing yeast, spermidine treatment triggeres epigenetic deacetylation of histone H3 through...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-04 | E-MTAB-912 | biostudies-arrayexpress
ProteomicsIdentification of proteins in proximity to VAP and VPS13L1 in P. falciparum blood stages
P. falciparum blood stage parasites maintain an intricate system of membranes, requiring precise mechanisms of lipid synthesis and trafficking. Lipid transfer proteins (LTPs) at interorganelle membrane contact sites (MCSs) have emerged as key for ensuring proper lipid distribution in cells but so fa...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-07-28 | PXD066159 | Pride
Malaria Membrane contact sites Erythrocytic stages Lipid transfer proteins Bioid 
ProteomicsCharacterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
Introduction: Ampullary cancer is a relatively rare entity and usually treated by pancreatoduodenectomy followed by adjuvant therapy. The intestinal subtype is associated with markedly improved prognosis after resection. Only few cell lines are available for in vitro studies of ampullary cancer and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080802 | MassIVE
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
GenomicsInternational Multi-Center ADHD Gene Project (IMAGE) II Case Sample

This sample represents a collection of cases across a range of sites. All of these samples were ascertained for ADHD with most meeting criteria for combined type ADHD. The collection sites span Europe and America. Further details on the source and inclusion and exclusion information can be found ...

phs000407.v1.p1 | EGA
GenomicsThe PUWMa (Pfizer-funded study from the University of California Los Angeles (UCLA), Washington University (WASH-U), and Massachusetts General Hospital (MGH)) GWAS of ADHD

The PUWMa GWAS of ADHD is a multi-site collaboration initiated to conduct a family-based association study from existing research samples. The source sample of ADHD families was ascertained at Massachusetts General Hospital (MGH, N=309 trios), Washington University at St. Louis (WASH-U, N...

phs000358.v1.p1 | EGA
ProteomicsMitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Cytotoxic T cell (CTL) dysfunction is a key feature of immune paralysis following major surgery, significantly increasing the risk of severe nosocomial infections and contributing to elevated mortality in critically ill patients. The pathomechanisms of CTL dysfunction remain unclear. We report that ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-04 | MSV000097035 | MassIVE
ProteomicsMass spectrometry-based draft of the mouse proteome
Quantitative draft map of the proteomes of 41 healthy tissues of the animal model Mus musculus and a panel of 66 murine pancreatic ductal adenocarcinoma cell lines and. Our in-depth analysis provides evidence for proteins encoded by >16,000 genes (~76% of the total annotated protein-coding genes), w...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-07-09 | MSV000089856 | MassIVE
UnknownThe HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
Not available
S-SCDT-EMM-2021-13952 | biostudies-other
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