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MetabolomicsAspartate potentiates tobramycin against multidrug-resistant Edwardsiella tarda through enhancing proton motive force and membrane permeability

The antibiotic susceptibility/resistance of bacteria is influenced by their metabolic states. In tobramycin-resistant Edwardsiella tarda (LTB4-RToB), a dynamic metabolic state is observed, characterized by a general reduction in most metabolites as the minimum inhibitory concentration (MIC) incre...

2025-07-31 | MTBLS12725 | MetaboLights
TranscriptomicsTranscription profiling of planktonic pseudomonas aeruginosa exposed to tobramycin treatment
As a comparison to tobramycin-treated P. aeruginosa biofilms, we investigated the response of planktonic P. aeruginosa to tobramycin by microarray. Experiment Overall Design: We included 2 control (untreated) cultures and 2 tobramycin-treated cultures. We used mid-exponential phase cultures of P. a...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-21 | E-GEOD-9991 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Pseudomonas aeruginosa treated with tobramycin
This SuperSeries is composed of the following subset Series:; GSE9989: Tobramycin Treatment of P. aeruginosa Biofilms Grown on CFBE41o- Cells; GSE9991: Tobramycin Treatment of Planktonic Pseudomonas aeruginosa Experiment Overall Design: Refer to individual Series
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-18 | E-GEOD-10030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of P. aeruginosa biofilms treated with tobramycin grown on CFBE41o- cells
We grew Pseudomonas aeruginosa biofilms on CFBE41o- human airway cells in culture, and we treated these biofilms with tobramycin. Microarray analysis was performed to gain an understanding of the global transcriptional changes that occur during antibiotic treatment. Experiment Overall Design: We co...
ORGANISM(S): Pseudomonas aeruginosa 
2008-06-18 | E-GEOD-9989 | biostudies-arrayexpress
GenomicsExperimental evolution of Pseudomonas aeruginosa biofilms exposed to furanone C-30 with and without tobramycin
The aim of this study is to evaluate the evolutionary robustness of the quorum sensing inhibitor (QSI) furanone C-30 for the treatment of P. aeruginosa biofilm infections. We repeatedly exposed P. aeruginosa biofilms to furanone C-30 (with or without tobramycin) in the synthetic cystic fibrosis sput...
ORGANISM(S): Pseudomonas aeruginosa 
2021-03-05 | E-MTAB-10124 | biostudies-arrayexpress
TranscriptomicsSessile burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species
In the present study we wanted to investigate the molecular mechanisms responsible for the tobramycin tolerance in Burkholderia cenocepacia J2315 biofilms.
ORGANISM(S): Burkholderia cenocepacia 
2012-02-01 | E-MEXP-3532 | biostudies-arrayexpress
TranscriptomicsKristen-PAO1-anaerobic lethal concentrations tobramycin
To see the effects of tobramycin on Pseudomonas aeruginosa under anaerboc lethal conditions. RNA was isolated from 5 biological repeats of P.aeruginosa grown in cationic adjusted mueller hinton broth containing 15mM KNO3 and 5 biological repeats of P.aeruginosa grown in cationic adjusted mueller hi...
ORGANISM(S): Pseudomonas aeruginosa 
2011-01-20 | E-FPMI-24 | biostudies-arrayexpress
TranscriptomicsKristen-PAO1 aerobic sub-inhibitory cond. tobramycin
To see the effect of sub-inhibitory concentrations of tobramycin on Pseudomonas aeruginosa grown under aerobic conditions. RNA was isolated form 4 biological repeats of P.aeruginosa grown to mid-log in cationic adjusted mueller hinton broth and 4 biological repeats of P.aeruginosa with the addition ...
ORGANISM(S): Pseudomonas aeruginosa 
2011-03-30 | E-FPMI-23 | biostudies-arrayexpress
TranscriptomicsKristen-PAO1 aerobic lethal concentrations of Tobramycin
To see the effect of lethal concentrations of tobramycin on Pseudomonas aeruginosa grown under aerobic conditions. RNA was isolated from 4 biological repeats of P.aeruginosa grown to mid-log in cationic adjusted mueller hinton broth containing 15mM KNO3 and 4 biological repeats of P.aeruginosa grow...
ORGANISM(S): Pseudomonas aeruginosa 
2011-01-20 | E-FPMI-26 | biostudies-arrayexpress
TranscriptomicsKristen-PAO1-anaerobic sub-lethal concentrations tobramycin
To see the effect of sub-lethal concentration of tobramcyin on PAO1 under anaerobic conditions. RNA was isolated from 5 biological repeats of PAO1 grown to mid-log phase in cationic adjusted mueller hinton broth containing 15mM KNO3 and 5 biological repeats of PAO1 grown to mid-log phase in cationi...
ORGANISM(S): Pseudomonas aeruginosa 
2011-01-20 | E-FPMI-25 | biostudies-arrayexpress
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