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TranscriptomicsGenes regulated by miR-34b/c and DAC
We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC....
ORGANISM(S): Homo sapiens 
2008-04-30 | E-GEOD-10455 | biostudies-arrayexpress
TranscriptomicsIdentification of targets specifically regulated by a 'super hybrid p53'
p63, like its homologue, the tumor suppressor p53, is also able to induce apoptosis in several cancer cell types. p53 family proteins are composed of three characteristic domains which are: 1) an N-terminal transactivation domain (TAD); 2) a central DNA-binding domain (DBD); and 3) an oligomerizatio...
ORGANISM(S): Homo sapiens 
2012-02-04 | E-GEOD-35512 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in HuH7 cells transfected with super hybrid p53 version 2.
The p53 tumor suppressor belongs to a gene family that includes two other structurally and functionally related members: p63 and p73. However, the regulation of p53 activity differs significantly from that of p73 and p63. To enhance the tumor suppressive activity of p53, we created a p63/p53 hybrid ...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-42493 | biostudies-arrayexpress
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