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TranscriptomicsExpression Profile-Defined Classification of Lung Adenocarcinoma
Expression profiles of 18,175 unique genes and three major genetic changes, p53, EGFR and K-ras, were investigated in 149 patients with non-small cell lung cancer (NSCLC), including 90 patients with adenocarcinomas (AD) to determine their relationships with various clinicopathologic features and Gen...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-11969 | biostudies-arrayexpress
TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
TranscriptomicsPre-miR-375_A549 vs. Pre-miR-NC#2 (Ambion) _A549
We investigated the functional significance of ASH1-inducible miR-375 in terms of biologic phenotypes of ASH1-positive lung cancer cells. To this end, we conducted genome-wide expression profiling analysis of miR-375-transfected A549 cells. Microarray analysis using a Whole Human Genome 4 x 44K Micr...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-31566 | biostudies-arrayexpress
TranscriptomicsASH1_A549 vs. vector control_A549
We performed genome-wide expression profiling of miRNAs in order to search for those significantly affected by ASH1 transduction in a lung cancer cell line. Microarray analysis was?conducted to examine miRNA expression profiles using a Human miRNA Microarray, pre-commercial version 6.0 (Agilent) wit...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-31565 | biostudies-arrayexpress
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