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UnknownCombined DECS Analysis and Next-Generation Sequencing Enable Efficient Detection of Novel Plant RNA Viruses.
The presence of high molecular weight double-stranded RNA (dsRNA) within plant cells is an indicator of infection with RNA viruses as these possess genomic or replicative dsRNA. DECS (dsRNA isolation, exhaustive amplification, cloning, and sequencing) analysis has been shown to be capable of detecti...
S-EPMC4810260 | biostudies-literature
UnknownIdentification of a novel viral factor inducing tumorous symptoms by disturbing vascular development in planta.
Plant viruses induce various disease symptoms that substantially impact agriculture, but the underlying mechanisms of viral disease in plants are poorly understood. Kobu-sho is a disease in gentian that shows gall formation with ectopic development of lignified cells and vascular tissues such as xyl...
S-EPMC10537666 | biostudies-literature
ProteomicsTargeted proteome analysis of the central carbon metabolism related enzymes in S. cerevisiae mutant strains
Expression profiles of 110 the central metabolism-related enzymes were obtained by the selected reaction monitoring (SRM) assay methods using LC-MS/MS from the wild type (BY4742), a GCR2 gene deletion strain, and 29 single-gene deletion strains lacking enzyme genes responsible for central carbon met...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2017-03-22 | PXD004714 | JPOST Repository
UnknownEfficacy and safety of brodalumab, an anti-IL17RA monoclonal antibody, in patients with axial spondyloarthritis: 16-week results from a randomised, placebo-controlled, phase 3 trial.

Objective

To investigate the efficacy and safety of brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, in patients with axial spondyloarthritis (axSpA).

Methods

In a multicentre, placebo-controlled phase 3 study (NCT02985983) conducted at 48 sites across Jap...
S-EPMC8292606 | biostudies-literature
UnknownContinuing versus withdrawing ixekizumab treatment in patients with axial spondyloarthritis who achieved remission: efficacy and safety results from a placebo-controlled, randomised withdrawal study (COAST-Y).

Objectives

The objective of COAST-Y was to evaluate the effect of continuing versus withdrawing ixekizumab (IXE) in patients with axial spondyloarthritis (axSpA) who had achieved remission.

Methods

COAST-Y is an ongoing, phase III, long-term extension study that included a double-blin...
S-EPMC8292566 | biostudies-literature
UnknownLow-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate: subanalysis from the JPAD trial.

Objective

Type 2 diabetes accompanied by renal damage is a strong risk factor for atherosclerotic events. The purpose of this study was to investigate the efficacy of low-dose aspirin therapy on primary prevention of atherosclerotic events in patients with type 2 diabetes and coexisting rena...
S-EPMC3024334 | biostudies-literature
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