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TranscriptomicsExpression data from Fog1+/+ and Fog1 ki/ki mouse megakaryocyte-erythroid progenitors (MEP).
The transcription co-factor FOG1 interacts with the chromatin remodeling complex NuRD to mediate gene activation and gene repression during hematopoiesis. We have generated mice with a targeted mutation in the endogenous Fog1 locus that results in an N-ternimal mutation in FOG1 that disrupts the int...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-19497 | biostudies-arrayexpress
UnknownMiR-140-5p targets Prox1 to regulate the proliferation and differentiation of neural stem cells through the ERK/MAPK signaling pathway.
Not available
S-EPMC8106095 | biostudies-literature
TranscriptomicsComparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic Acid on rat kidneys
RNA-Seq has been increasingly used for the quantification and characterization of transcriptomes. The ongoing development of the technology promises the more accurate measurement of gene expression. However, its benefits over widely accepted microarray technologies have not been adequately assessed,...
ORGANISM(S): Rattus norvegicus 
2012-02-02 | E-GEOD-21210 | biostudies-arrayexpress
TranscriptomicsEffect of JMJD2B depletion on the ER signaling pathway
JMJD2B is expressed in a high proportion of human breast tumors, and the expression levels significantly correlate with estrogen receptor (ER) positivity. To assess the effect of JMJD2B depletion on the ER signaling pathway, we performed genome-wide gene expression analysis using the Affymetrix Huma...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-23445 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of gastric cancer SGC-7901 cells in response to stable over-expression of intelectin 1
Gastric cancer is one of the most common cancers worldwide, with approximately 1 million patients being diagnosed annually. Better elucidating the mechanisms of tumorigenesis and aggressiveness is important for improving the therapeutic efficiencies of gastric cancer. Since our previous studies indi...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-58962 | biostudies-arrayexpress
TranscriptomicsALKBH5 is a New Mammalian RNA Demethylase
N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as a new mammalian demethylase that oxidatively removes the m6A modification in mRNA in vitro and inside cells. This demethylation activity of ALKBH5 significantly...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-40132 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
UnknownEffect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC10326520 | biostudies-literature
UnknownSimvastatin in Critically Ill Patients with Covid-19.
Not available
S-EPMC10755839 | biostudies-literature
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
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