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ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
ProteomicsElucidation of tonic and activated B cell receptor signaling in Burkitt’s lymphoma provides insights into regulation of cell survival
B-cell receptor (BCR) signaling promotes the survival of malignant B cells, such as Burkitt’s lymphoma (BL) and the activated B-cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL). In contrast to ABC DLBCL, where malignant cells require chronic activation of the BCR for their survival, BL...
ORGANISM(S): Homo sapiens (Human) 
2016-05-09 | PXD003492 | Pride
B cell receptor Phosphoproteome Lymphoma Cancer biology 
GenomicsATAC-seq profiling of human Tregs and conventional CD4+ cells that were transduced with a non-tonic signaling (CD19) or a tonic signaling (HA) CAR
ATAC-seq profiling of human Tregs and conventional CD4+ cells that were transduced with a non-tonic signaling (CD19) or a tonic signaling (HA) CAR
PRJNA862550 | ENA
GenomicsTonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
PRJNA862080 | ENA
GenomicsA Tonic Signaling Code Governs CAR-T Cell Efficacy in Diffuse Midline Glioma
A Tonic Signaling Code Governs CAR-T Cell Efficacy in Diffuse Midline Glioma
PRJNA1308832 | ENA
GenomicsDynamic control of transcriptional regulator BACH2 overcomes T cell dysfunction driven by tonic CAR signaling
Dynamic control of transcriptional regulator BACH2 overcomes T cell dysfunction driven by tonic CAR signaling
PRJNA1212030 | ENA
GenomicsRNA-seq profiling of human Tregs and conventional CD4+ cells that were left untransduced or transduced with a non-tonic signaling (CD19) or a tonic signaling (HA) CAR
RNA-seq profiling of human Tregs and conventional CD4+ cells that were left untransduced or transduced with a non-tonic signaling (CD19) or a tonic signaling (HA) CAR
PRJNA642176 | ENA
GenomicsAmbient temperature regulates CD4⁺ T cell tonic T cell receptor signaling and responsiveness
Ambient temperature regulates CD4⁺ T cell tonic T cell receptor signaling and responsiveness
PRJNA1365249 | ENA
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo sapiens (Human) 
2017-01-02 | PXD004181 | Pride
Hsp90 Burkitt’s lymphoma Bcr signaling Mass spectrometry Syk Phosphoproteomics 
UnknownEngineering γδT cells limits tonic signaling associated with chimeric antigen receptors.
Not available
S-EPMC7055420 | biostudies-literature
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