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ProteomicsCholesterol binding to VCAM-1 promotes vascular inflammation
Hypercholesterolemia has long been implicated in endothelial cell (EC) dysfunction, but the mechanisms by which excess cholesterol causes vascular pathology are incompletely understood. Here we used a cholesterol-mimetic probe to map cholesterol-protein interactions in primary human ECs and discover...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000099325 | MassIVE
TranscriptomicsLXR activation in RAW264.7 mouse macrophages expressing LXRalpha.
To identify novel LXR target genes, we conducted transcriptional profiling studies using RAW264.7 cells ectopically expressing LXRalpha Total RNA was isolated from RAW264.7 macrophages ectopically expressing LXRalpha as described in Venkateswaran et al. (2000); PNAS 97, 12097-12102. Cells were cult...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-17088 | biostudies-arrayexpress
TranscriptomicsMouse Hepatocytes +/- GW
Identification of novel LXR target genes Primary mouse hepatocytes were isolated from Bl6 mice and plated on 6 well plates. Cells serum starved and treated with statin/MVA followed by overnight adminstration of DMSO or LXR agonist GW3965. Total RNA isolation using TRIZOL and Qiagen Column.
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-77786 | biostudies-arrayexpress
TranscriptomicsMouse Liver LeXis overexpression
Consequences of hepatic Lexis overexpression Mouse livers treated with AdLeXis or AdGFP
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-77802 | biostudies-arrayexpress
TranscriptomicsMouse Liver Raly knockdown
Effects of Raly knockdown on hepatic gene expression Mouse livers treated with adenoshRaly or control
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-77805 | biostudies-arrayexpress
TranscriptomicsAdipose subtype-selective recruitment of TLE3 in thermogenic gene programs
Transcriptional effectors of white adipocyte-selective gene expression have not been described. TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective cofactor Prdm16 to specify lipid storage and thermogenic gene programs. When expressed at elevated levels in brown fat, T...
ORGANISM(S): Mus musculus 
2013-09-27 | E-GEOD-51223 | biostudies-arrayexpress
TranscriptomicsPhysiological Vascular Permeability Requires Induction of Endothelial NR4A1 by Progesterone Receptor [RNA-Seq]
Vascular permeability is frequently associated with inflammation and it is triggered by chemokines and by a cohort of secreted permeability factors, such as VEGF. In contrast, here we showed that the physiological vascular permeability that precedes implantation is directly controlled by progestero...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43788 | biostudies-arrayexpress
GenomicsPhysiological Vascular Permeability Requires Induction of Endothelial NR4A1 by Progesterone Receptor [ChIP-Seq]
Vascular permeability is frequently associated with inflammation and it is triggered by chemokines and by a cohort of secreted permeability factors, such as VEGF. In contrast, here we showed that the physiological vascular permeability that precedes implantation is directly controlled by progestero...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-43786 | biostudies-arrayexpress
TranscriptomicsGene expression during ligands activation of RXR in activated RAW264.7 cells
Ligands activation of RXR modulate host antivarl response. We used microarray to determine if 9cRA could regulate the antiviral gene expression in LPS- and polyI:C triggered RAW264.7 cells. RAW 264.7 cells were pre-treated with DMSO or 100nM of 9cis-retinoic acid for 16hours. The cells were then st...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-62107 | biostudies-arrayexpress
TranscriptomicsGene expression of livers from Lpcat3fl/fl and Lpcat3fl/fl Albumin-Cre mice on a western diet
The total abundance of phosphatidylcholine (PC) is known to influence lipoprotein production. However, the role of specific phospholipid species in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the LXR-reg...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-65353 | biostudies-arrayexpress
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