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TranscriptomicsTranscription profiling of tooth germs from mouse fetuses and embryos
Study of changes in gene expression in mouse tooth germs between E15.5 and 21.5dpc
ORGANISM(S): Mus musculus 
2007-04-01 | E-MEXP-947 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse molar tooth development
To identify genes heretofore undiscovered as critical players in the biogenesis of teeth, we have used microarray gene expression analysis of the developing mouse molar tooth (DMT) between 1 and 10 days postnatal to identify genes differentially expressed when compared to 16 control tissues (GEO acc...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7164 | biostudies-arrayexpress
TranscriptomicsNext-generation sequencing facilitates quantitative analysis of wild type and Bmp4f/f;Wnt1Cre tooth mesenchyme transcriptomes
Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition. Whereas the bud stage tooth developmental arrest in Msx1-/- mutant mice was accompanied by reduction in mesenchymal Bmp4 mRNA expression...
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-39918 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of first molar tooth germ in PPAR-alpha knock-out and wild type mice
Embryologically the tooth is derived from both the ectoderm and neural crest (ectomesenchyme). It is often used as a model to study how epithelial–mesenchymal interactions can control differentiation and morphogenesis. During early development organs of ectodermal origin share both a set of signalli...
ORGANISM(S): Mus musculus 
2009-08-06 | E-MTAB-42 | biostudies-arrayexpress
TranscriptomicsSingle cell transcriptional profiling of mouse molar and incisor tooth assembloids
Throughout the various stages of tooth development, reciprocal epithelial-mesenchymal interactions are the driving force, for instance crucially involved in the differentiation of mature enamel-forming ameloblasts and dentin-producing odontoblasts. Here we established mouse tooth ‘assembloids’, comp...
ORGANISM(S): Mus musculus 
2023-04-19 | E-MTAB-12544 | biostudies-arrayexpress
TranscriptomicsA Wnt-Bmp feedback circuit controls inter-tissue signaling dynamics in tooth organogenesis
Gene expression profiling of the epithelial and mesenchymal compartments of the developing mouse tooth using Laser Capture Microdissected (LCM) or enzymatic treatment with Dispase to isolate the dental epithelial and mesenchymal tissue, over a developmental period from E10.0-E14.5. The data is also ...
ORGANISM(S): Mus musculus 
2012-01-13 | E-GEOD-32321 | biostudies-arrayexpress
ProteomicsMouse periodontal ligament tissue after orthodontic tooth movement
Mouse periodontal ligament tissue after orthodontic tooth movement for 14 days. Tissue was dissected by a laser microdissection microscope. Samples were analyzed separately at mesial (compression) and distal (tension) sides.
ORGANISM(S): Mus Musculus (mouse) 
2022-12-16 | PXD030430 | JPOST Repository
TranscriptomicsMicroarray expression profiling of mRNAs in the developing murine first molar tooth ge
The global gene expression of murine tooth germs dissected at various stages of tooth development was investigated. A list of genes differentialy expressed throughout the various time points was submitted to bioinformatic analysis using Ingenuity Pathway Analysis (IPA) to identify significant assoc...
ORGANISM(S): Mus musculus 
2012-11-14 | E-MEXP-3581 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Identifies Hoxa1 and Hoxc13 as Downstream Targets of Yap in Mouse Epithelial Tissues
The goals of this study are to identify in vivo downstream targets of Yap through NGS-derived tooth germ transcriptome profiling. The mRNA profiles of wild-type, Yap conditional knockout (CKO) and YAP transgenic (Tg) mouse tooth germs at embryonic day 14.5 were generated by deep sequencing using Ill...
ORGANISM(S): Mus musculus 
2015-02-21 | E-GEOD-65524 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptional profiling of primary human dental follicle and derived organoids
Knowledge on tooth epithelial stem cells and corresponding biology in humans is sparse. Here, we developed an organoid model, typically replicating epithelial tissue stem cell biology, starting from human tooth. Dental follicle (DF), isolated from extracted wisdom teeth, efficiently generated long-t...
ORGANISM(S): Homo sapiens 
2022-04-01 | E-MTAB-10596 | biostudies-arrayexpress
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