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MetabolomicsCirculating Metabolites in Progression to Islet Autoimmunity and Type 1 Diabetes

AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a cir...

2022-01-19 | MTBLS802 | MetaboLights
MetabolomicsPersistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease

OBJECTIVES: Celiac disease (CD) is a chronic enteropathy characterized by an autoimmune reaction in the small intestine of genetically susceptible individuals. The underlying causes of autoimmune reaction and its effect on host metabolism remain largely unknown. Herein, we apply ...

2020-01-22 | MTBLS729 | MetaboLights
MetabolomicsMetabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreat...

2020-08-10 | MTBLS1015 | MetaboLights
MetabolomicsDynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes: Type 1 Diabetes Prediction and Prevention Study (DIPP)
Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 pl...
2018-07-16 | MTBLS620 | MetaboLights
ProteomicsSerum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Aims/hypothesis: Biomarkers are needed to accurately predict and monitor type 1 diabetes progression during the substantially heterogeneous presymptomatic period of the disease development. To address this concern, we studied temporal changes in the plasma and serum proteomes of < 5-year-old childre...
ORGANISM(S): Homo Sapiens 
PXD033946 | panorama
ProteomicsD6_iTRAQ
D6_1 and D6_2 are 8 plex iTRAQ analyses of depleted serum samples. The file represents mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078752 | MassIVE
ProteomicsLongitudinal study
iTRAQ labelled depleted serum, SCX fractionated, RP-LC Orbitrap-Velos
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-23 | MSV000078746 | MassIVE
ProteomicsD18_LF
Thermo RAW files Case18T and Control18T (Case and Cont) represent D18 and Control-18 and are marked by their visit number. These are label free analyses of depleted serum samples conducted with an Orbitrap Velos - Proxeon capillary LC combination. CID fragmentation was used. The samples were analyze...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-25 | MSV000078764 | MassIVE
ProteomicsD13_iTRAQ
D13_1, and D13_2 are 8 plex iTRAQ analyses of depleted serum samples. The files are group files of ProteinPilot analyses of the collected SCX fractions .
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078757 | MassIVE
ProteomicsD11_iTRAQ
D11_2 and D11_3 are 8 plex iTRAQ analyses of depleted serum samples. The files are mgf files of collected SCX fractions that were analyzed with an Orbitrap Velos- Proxeon capillary LC combination. HCD fragmentation was used.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-06-24 | MSV000078758 | MassIVE
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