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TranscriptomicsIdentification of glucose-TOR signaling early target genes in Arabidopsis seedling autotrophic transition stage
The goal of this experiment was to explore the molecular network of glucose-TOR signaling in Arabidopsis seedling autotrophic transition stage. We used the whole-genome microarrays to detail the global program of gene expression mediated by glucose and TOR. Arabidopsis WT and estradiol inducible RNA...
ORGANISM(S): Arabidopsis thaliana 
2013-04-05 | E-GEOD-40245 | biostudies-arrayexpress
ProteomicsFunctional Characterization of Target of Rapamycin (TOR) Signalling in Physcomitrella
Target of rapamycin (TOR) is a structurally and functionally conserved protein kinase and an important signalling hub in eukaryotes. The moss Physcomitrella (Physcomitrium patens) is a model organism for plant physiology, development, and evolution. However, little is known about TOR signalling in n...
ORGANISM(S): Physcomitrella Physcomitrella patens subsp. patens (Moss) 
2026-02-09 | PXD069889 | Pride
Physcomitrella Tor signalling 
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
TranscriptomicsSynergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth
The experiments were designed to interrogate the genetic interaction relationship between the TOR signalling pathway and the UPS-proteasome pathway in gene expression and cell growth. Yeast cells (BY4742pdr5delta) were treated with the drug vehicle, MG132 (50uM), rapamycin (200ng/ml) or both drugs. ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-05-24 | E-MTAB-1550 | biostudies-arrayexpress
TranscriptomicsIdentification of new target genes of TOR during growth in MDN
To identify novel targets of TOR when prototrophic strain S288c is grown in MDN media. Arrays compare growth in MDN with and without addition of rapamycin. For comparison, growth in YPD versus MDN as well as SCD versus MDN were examined as well.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-30 | E-GEOD-3157 | biostudies-arrayexpress
GenomicsTOR-NOT4 signalling couples translation to co-translational quality control in plants
TOR-NOT4 signalling couples translation to co-translational quality control in plants
PRJNA1425501 | ENA
TranscriptomicsDifferentially regulated genes in TOR knockdown Arabidopsis lines
Rapamycin-sensitive transgenic Arabidopsis lines (BP12) expressing yeast FK506 Binding Protein12 (FKBP12) were developed. Inhibition of TOR in BP12 plants by rapamycin resulted in slower overall root, leaf and shoot growth and development leading to poor nutrient uptake and light energy utilization....
ORGANISM(S): Arabidopsis thaliana 
2012-12-18 | E-GEOD-42968 | biostudies-arrayexpress
TranscriptomicsExploring the scope of TOR/PKA co-regulation in MDN
To identify genes co-regulated by TOR and PKA during growth in MDN BCY1, bcy1 deletion, TPK, and tpk1-3 deletion strains were grown in MDN with and without rapamycin treatment. Different combinations of these samples were examined.
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-3160 | biostudies-arrayexpress
ProteomicsIdentification of a TOR-regulated phosphoproteome and the regulation of cellular protein synthesis
We describe an in depth analysis in fission yeast of changes in the phosphoproteome after inhibition of the TOR protein kinases. A total of 756 phosphosites on 316 proteins showed significant and rapid changes in phosphorylation levels after TOR kinase inhibition when the rate of protein synthesis r...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2021-07-09 | PXD023664 | Pride
Phosphoproteomics Fission yeast Tmt S. pombe Tor 
UnknownGlucose-TOR signalling reprograms the transcriptome and activates meristems.
Not available
S-EPMC4140196 | biostudies-literature
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