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TranscriptomicsA microRNA blueprint for early atrial remodeling in a porcine model of paroxysmal atrial fibrilation
Spontaneous paroxysmal atrial fibrillation (PAF) is one of the very common heart rhythm disorders. The molecular mechanisms underlying PAF susceptibility and persistence are multiple and incompletely understood. To study the contribution of microRNAs (miRNAs) to the development and perpetuation of P...
ORGANISM(S): Sus scrofa 
2016-07-03 | E-GEOD-65330 | biostudies-arrayexpress
TranscriptomicsCardiac gene expression analysis in porcine model of heart failure
A gene expression topology of the developing, postnatal and diseased heart resulted in re-interpretation of ventricular remodeling in terms of rearrangement of key gene regulatory networks that are imbalanced, attenuated, or abnormally activated in the failing myocardium. The underlying principle, “...
ORGANISM(S): Sus scrofa 
2012-05-31 | E-GEOD-30110 | biostudies-arrayexpress
ProteomicsIdentification of PWWP2A interactors using label-free quantitative affinity enrichment mass spectrometry
Chromatin structure and function is regulated by reader proteins recognizing histone modifications and/or histone variants. We recently identified PWWP2A as a binder for H2A.Z-containing nucleosomes (Pünzeler, S. et al., EMBO J 2017). Here, as part of a larger project trying to characterize PWWP2A, ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-30 | PXD010202 | Pride
Ap-ms Ae-ms Mta1 Nurd Pwwp2a Interaction proteomics Histone variants Label-free quantification H2a.z 
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