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TranscriptomicsGene expression profiling of MOLT4 human T-ALL cells in response to miR-22-3p overexpression
MicroRNAs can play important roles in gene regulation affecting both normal development and diseases, including cancer. This microarray experiment was performed to identify genes and pathways differentially expressed in MOLT4 T-leukemia cells engineered to overexpress hsa-pre-miR-22-3p. MOLT4 cells...
ORGANISM(S): Homo sapiens 
2020-07-30 | E-MTAB-9280 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of mouse NOTCH1-induced tumors following in vivo treatment with gamma-secretase inhibitor
NOTCH1 is a transcription factor involved in T-cell development and mutations that occur in NOTCH1 gene affects more than 60% of patients affected by T-cell acute lymphoblastic leukemia (T-ALL). In order to identify microRNAs regulated following NOTCH1 inhibition in T-ALL, murine NOTCH1-induced T-ce...
ORGANISM(S): Mus musculus 
2020-07-30 | E-MTAB-9278 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse NOTCH1-induced tumors following in vivo treatment with gamma-secretase Inhibitor
NOTCH1 is a transcription factor involved in T-cell development and mutations that occur in NOTCH1 gene affects more than 60% of patients affected by T-cell acute lymphoblastic leukemia (T-ALL). In order to identify genes and pathways regulated following NOTCH1 inhibition in T-ALL, murine NOTCH1-ind...
ORGANISM(S): Mus musculus 
2020-07-30 | E-MTAB-9279 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Early immature and Late mature T-ALL cell lines
Early immature T-cell acute lymphoblastic leukemias (T-ALLs) account for about 5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. Analysis of microarray gene expression signatures in adult T-AL...
ORGANISM(S): Homo sapiens 
2013-06-18 | E-GEOD-48046 | biostudies-arrayexpress
TranscriptomicsGene Expression Analyisis of T-ALL LOUCY cell lines treated with ETV6 siRNA vs. scramble control siRNA
Transcriptional effects of ETV6 inactivation in immature T-ALL were investigated by gene expression analysis upon siRNA-mediated knockdown of ETV6 in LOUCY cells, a T-ALL cell line with a transcriptional program highly related to that of immature T-ALLs. Gene Set Enrichment Analysis (GSEA) of the ET...
ORGANISM(S): Homo sapiens 
2011-11-24 | E-GEOD-33820 | biostudies-arrayexpress
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