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TranscriptomicsTime-resolved immune dynamics in rheumatoid arthritis under methotrexate therapy
Methotrexate (MTX) serves as the primary treatment for rheumatoid arthritis (RA), though its mechanism of action is not yet fully understood. The goal of this study was to map the cellular and molecular changes triggered by MTX across different points in time. Using a prospective longitudinal design...
ORGANISM(S): Homo sapiens 
2026-07-01 | E-MTAB-17153 | biostudies-arrayexpress
TranscriptomicsNicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is characterized by progressive skin and organ fibrosis driven by persistently activated fibroblasts, however, the mechanisms of dermal fibroblast (DF) activation remain unclear. Nicotinamide N-methyltransferase (NNMT) has been linked to fibrosis in other diseases, but its r...
ORGANISM(S): Homo sapiens 
2026-10-20 | E-MTAB-17207 | biostudies-arrayexpress
TranscriptomicsNicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is characterized by progressive skin and organ fibrosis driven by persistently activated fibroblasts, however, the mechanisms of dermal fibroblast (DF) activation remain unclear. Nicotinamide N-methyltransferase (NNMT) has been linked to fibrosis in other diseases, but its r...
ORGANISM(S): Homo sapiens 
2026-10-20 | E-MTAB-17206 | biostudies-arrayexpress
TranscriptomicsNicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis
Systemic sclerosis (SSc) is characterized by progressive skin and organ fibrosis driven by persistently activated fibroblasts, however, the mechanisms of dermal fibroblast (DF) activation remain unclear. Nicotinamide N-methyltransferase (NNMT) has been linked to fibrosis in other diseases, but its r...
ORGANISM(S): Homo sapiens 
2026-10-21 | E-MTAB-15932 | biostudies-arrayexpress
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