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TranscriptomicsKetamine and Imipramine Reverse Transcriptional Signatures of Susceptibility and Induce Resilience-Specific Gene Expression Profiles
Background: Examining transcriptional regulation by existing antidepressants in key neural circuits implicated in depression, and understanding the relationship to transcriptional mechanisms of susceptibility and natural resilience, may help in the search for new therapeutics. Further, given the het...
ORGANISM(S): Mus musculus 
2016-07-27 | E-GEOD-81672 | biostudies-arrayexpress
ProteomicsMitochondrial content normalization using mass spectrometry allows quantitative evaluation of intrinsic bioenergetic efficiency and the underlying proteome across mouse organs.
To separate global changes to metabolism from intrinsic mitochondrial remodeling, investigators commonly use isolated mitochondrial preparations obtained through differential centrifugation. This simple process has been reliably implemented in a variety of tissues to produce intact, functional mitoc...
ORGANISM(S): Mus Musculus (mouse) 
2021-07-09 | PXD020280 | JPOST Repository
TranscriptomicsTranscriptome profiling of deciduas from pre-eclamptic and normotensive pregnancies
Genome-wide analysis of decidual transcriptome in pre-eclampsia compared with normotensive controls to find differentially expressed genes/pathways. Preeclampsia (PE) is a common and serious pregnancy hypertensive disorder with a strong genetic component. The study aims were to use genome-wide analy...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-60438 | biostudies-arrayexpress
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