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TranscriptomicsGenome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive breast carcinoma (IBC). DNA methylation alterations are thought to be an early event in progression of cancer, and may prove valuable as a tool in clinical decision making and for understanding neoplastic development. Genome-wi...
ORGANISM(S): Homo sapiens 
2014-08-08 | E-GEOD-60185 | biostudies-arrayexpress
TranscriptomicsLentiviral transduction of CD34+ cells induces genome-wide epigenetic modifications
Human CD34+ cells were cultured shortly in the presence of cytokines then with a gene transfer lentiviral vector (LV) expected to transduce cells but to have otherwise limited biological effects on the cells. At the end of the culture, the population of cells remained largely similar at the phenotyp...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40631 | biostudies-arrayexpress
TranscriptomicsIndividual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors
Background: The global effect of copy number and epigenetic alterations on miRNA expression in cancer is poorly understood. In the present study, we integrate genome-wide copy number, DNA methylation and miRNA expression and identify genetic mechanisms underlying miRNA dysregulation in breast cancer...
ORGANISM(S): Homo sapiens 
2013-10-24 | E-GEOD-46934 | biostudies-arrayexpress
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