Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

Chronic sleep loss profoundly impacts metabolic health and shortens lifespan, but studies of the mechanisms involved have focused largely on acute sleep deprivation. To identify metabolic consequences of chronically reduced sleep, we conducted unbiased metabolomics on heads of three adult Drosoph...

Anthropogenic chemicals pose a threat to aquatic ecosystems by targeting the microalgal photosynthetic engines that drive primary production. Although the toxic effects of pollutants such as nonylphenol (NP) are well-acknowledged, the molecular mechanisms enabling microalgal resilience remain lar...

Desalination brine discharge poses emerging threats to benthic marine organisms through combined salinity stress and metal contamination. This study investigated the individual and combined effects of salinity (35 ppt) and metal exposure (Cu, Fe, and Cd) on the sea cucumber Apostichopus japonicus...

The widespread use of agricultural plastic films has made micro- and nanoplastics (MNPs) and phthalate esters (PAEs) contaminants of emerging concern in agroecosystems. However, the interactive mechanisms underlying their combined pollution in soil-plant systems remain elusive. To fill this gap, ...