Sort   by:  
 Page size 
MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
ProteomicsStaphylococcus aureus toxin-antitoxin system
Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. They express toxic peptides whose overexpression leads to growth arrest or cell death, whereas antitoxins regulate the expression of toxins, acting as labile antisense RNAs. The Staphylococcus aureus (S. aureus)...
ORGANISM(S): Staphylococcus aureus 
2021-07-05 | PXD023449 | Pride
S. aureus  toxin-antitoxin system  proteomics  cell death 
TranscriptomicsExpression profile for BW25113 M-NM-^TmqsRA with deoxycholate stress
MqsR/MqsA is a well-characterized toxin/antitoxin system with several regulatory roles. Deletion of mqsRA reduced growth with deoxycholate stress. Here we performed a microarray to determine the expression profile with and without mqsRA under deoxycholate stress to determine transcriptional regulat...
ORGANISM(S): Escherichia coli BW25113 
2015-01-09 | E-GEOD-59441 | biostudies-arrayexpress
GenomicsGrowth control switch by a DNA damage-inducible toxin-antitoxin system in Caulobacter
Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. However, it is not always clear whether specific targets of orthologous RNAse toxins are responsible f...
ORGANISM(S): Caulobacter crescentus NA1000 
2016-02-17 | E-GEOD-76721 | biostudies-arrayexpress
ProteomicsThe toxin from the PemIK-Sa1 toxin-antitoxin system decreases Staphylococcus aureus resistance to antibiotics
Toxin-antitoxin (TA) systems are bacteria-specific components involved in maintaining mobile genetic elements that may carry antibiotic resistance determinants (ARDs), among other functions. PemIK-Sa1 is a plasmid-encoded TA system found in Staphylococcus aureus, a dangerous pathogen affecting human...
ORGANISM(S): Staphylococcus aureus 
2026-08-16 | PXD077076 | Pride
Pemik-sal Toxin-antitoxin system S.aureus 
ProteomicsHipBA toxin-antitoxin system Caulobacter crescentus.
Antibiotic persistence is a transient phenotypic state during which a bacterium can withstand otherwise lethal antibiotic exposure or environmental stresses. In Escherichia coli, persistence is promoted by the HipBA toxin-antitoxin system. The HipA toxin functions as a serine/threonine kinase that i...
ORGANISM(S): Caulobacter crescentus (strain NA1000 / CB15N) 
2020-02-06 | PXD015525 | Pride
Caulobacter crescentus Phosphoproteome 
GenomicsProfiling the intragenic toxicity determinants of the hok/Sok toxin-antitoxin system
Profiling the intragenic toxicity determinants of the hok/Sok toxin-antitoxin system
PRJNA854135 | ENA
GenomicsHigh-throughput suppressor selection of a type I toxin-antitoxin system in Helicobacter pylori
High-throughput suppressor selection of a type I toxin-antitoxin system in Helicobacter pylori
PRJNA497299 | ENA
ProteomicsRegulation of Toxin-Antitoxin System savRS in Staphylococcus aureus Virulence and Host Key Signaling pathway
Staphylococcus aureus is an important pathogen with strong pathogenicity and serious threat to public health. The toxin-antitoxin system is considered to be contributed to the pathogenicity of S. aureus, but the exact pathogenic mechanism remains unknown. Our previous study showed that toxin-antitox...
ORGANISM(S): Mus Musculus 
2024-12-25 | PXD059235 |
GenomicsA novel prophage-encoded type III toxin–antitoxin system
A novel prophage-encoded type III toxin–antitoxin system promotes resistance to phage infection in Streptococcus pyogenes
PRJEB109274 | ENA
Sort   by:  
 Page size