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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
GenomicsE.coli toxin-antitoxin systems
E.coli toxin-antitoxin systems
PRJNA602532 | ENA
ProteomicsStaphylococcus aureus toxin-antitoxin system
Type I toxin-antitoxin (TA) systems are widespread genetic modules in bacterial genomes. They express toxic peptides whose overexpression leads to growth arrest or cell death, whereas antitoxins regulate the expression of toxins, acting as labile antisense RNAs. The Staphylococcus aureus (S. aureus)...
ORGANISM(S): Staphylococcus aureus 
2021-07-05 | PXD023449 | Pride
S. aureus  toxin-antitoxin system  proteomics  cell death 
GenomicsGrowth control switch by a DNA damage-inducible toxin-antitoxin system in Caulobacter
Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. However, it is not always clear whether specific targets of orthologous RNAse toxins are responsible f...
ORGANISM(S): Caulobacter crescentus NA1000 
2016-02-17 | E-GEOD-76721 | biostudies-arrayexpress
GenomicsStress induces the transcription of toxin-antitoxin systems but does not activate toxin
Stress induces the transcription of toxin-antitoxin systems but does not activate toxin
PRJNA593049 | ENA
TranscriptomicsExpression profile for BW25113 M-NM-^TmqsRA with deoxycholate stress
MqsR/MqsA is a well-characterized toxin/antitoxin system with several regulatory roles. Deletion of mqsRA reduced growth with deoxycholate stress. Here we performed a microarray to determine the expression profile with and without mqsRA under deoxycholate stress to determine transcriptional regulat...
ORGANISM(S): Escherichia coli BW25113 
2015-01-09 | E-GEOD-59441 | biostudies-arrayexpress
TranscriptomicsRNA-seq for identifying toxin MazF and MqsR cleavage sites in toxin expression and subsequent recovery cultures of Escherichia coli (mRNA and ncRNA excluding rRNA)
Bacterial toxin-antitoxin systems are thought to help bacteria to reduce their metabolism in various stressful conditions. Many toxins of the bacterial toxin-antitoxin systems are ribonucleases. Such toxins have been mostly viewed as degraders of mRNA, however recently it was demonstrated that they ...
ORGANISM(S): Escherichia coli K-12 
2018-10-11 | E-MTAB-6993 | biostudies-arrayexpress
ProteomicsHipBA toxin-antitoxin system Caulobacter crescentus.
Antibiotic persistence is a transient phenotypic state during which a bacterium can withstand otherwise lethal antibiotic exposure or environmental stresses. In Escherichia coli, persistence is promoted by the HipBA toxin-antitoxin system. The HipA toxin functions as a serine/threonine kinase that i...
ORGANISM(S): Caulobacter crescentus (strain NA1000 / CB15N) 
2020-02-06 | PXD015525 | Pride
Caulobacter crescentus Phosphoproteome 
OtherGlobal analysis of the specificities and targets of endoribonucleases from E. coli toxin-antitoxin systems
The purpose of this study was to identify the RNA cleavage targets and specificities of 9 endoribonuclease toxins from toxin-antitoxin systems in E. coli MG1655.
ORGANISM(S): Escherichia coli 
2021-07-13 | GSE179607 | GEO
ProteomicsA non-canonical type III toxin–antitoxin system encoded in Streptococcus pyogenes prophage promotes phage resistance
Toxin-antitoxin systems are widespread in bacteria. These systems typically consist of two components: a toxin that disrupts essential cellular processes and a cognate antitoxin that neutralizes its activity. However, their experimental characterization, particularly in the human pathogen Streptococ...
ORGANISM(S): Streptococcus pyogenes M1 GAS 
2026-09-23 | PXD084627 | Pride
Streptococcus pyogenes Toxin–antitoxin 
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