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TranscriptomicsIncreased X-ray sensitivity and sustained chromosomal stability in Ataxia Telangiectasia-derived induced pluripotent stem (AT-iPS) cells
Disease-specific induced pluripotent stem (iPS) cells have been used for a model to analyze pathogenesis of the disease. In this study, we generated iPS cells derived from a fibroblastic cell line of ataxia telangiectasia (AT-iPS cells), a neurodegenerative, inherited disease with chromosomal instab...
ORGANISM(S): Homo sapiens 
2013-06-22 | E-GEOD-47498 | biostudies-arrayexpress
TranscriptomicsPeriodic waves of aberrant DNA hyper-methylation in human iPS cells
We examined genome-wide DNA methylation with 22 human iPSC lines derived from different cell types and human ESC lines using Illumina’s Infinium HumanMethylation27 and focused on aberrant methylation sites in iPSCs for up to 42-week continuous cultivation. The iPSCs exhibited distinct epigenetic dis...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-24676 | biostudies-arrayexpress
TranscriptomicsGenomic alteration in MRC5-derived induced pluripotent stem (MRC5-iPS) cell line, Tic
Disease-specific induced pluripotent stem (iPS) cells have been used for a model to analyze pathogenesis of the disease. We generated iPS cells derived from a fibroblastic cell line of ataxia telangiectasia (AT-iPS cells). In analysis of AT-iPS cells, the human wild-type iPS cell line (MRC5-iPS) was...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-49082 | biostudies-arrayexpress
TranscriptomicsPeriodic waves of aberrant DNA hyper-methylation in human iPS cells (Agilent)
We examined genome-wide gene expression with human iPSC lines derived from different cell types, and human ESC lines using Agilent Whole Human Genome Microarray chips G4112F. Total RNA from 16 samples.
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-24677 | biostudies-arrayexpress
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