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TranscriptomicsGenes regulated by miR-34b/c and DAC
We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC....
ORGANISM(S): Homo sapiens 
2008-04-30 | E-GEOD-10455 | biostudies-arrayexpress
TranscriptomicsArray CGH analysis of human gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are the most important mesenchymal tumors of the gastrointestinal tract. The vast majority of GISTs exhibit activating mutations of KIT or PDGFRA, but epigenetic alteration of GISTs is largely unknown. In this study, we aimed to clarify the involvement of DN...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-22185 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CT116 cells and isogenic genetic knockouts rveals identity of the human cancer cell DNA hypermethylome
Altered gene expression is a hallmark of human cancers and arises in part through abnormal epigenetic regulation of gene transcription. The best characterized epigenetic alteration involves tumor suppressor gene inactivation via transcriptional repression associated with aberrant DNA hypermethylatio...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4763 | biostudies-arrayexpress
TranscriptomicsMCAM GIST
To examine methylation profile of the CpG promoters in clinical sample of GISTs.
ORGANISM(S): Homo sapiens 
2011-06-29 | E-TABM-1022 | biostudies-arrayexpress
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