Traf2 - OmicsDI

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Transcriptomics (465)
Unknown (443)
Genomics (83)
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Homo sapiens (102)
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Danio rerio (63)
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Oncorhynchus mykiss (18)
Saccharomyces cerevisiae (15)
Drosophila melanogaster (12)
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Organisms

Homo sapiens (38)
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pride (6)
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Immuno-osseus dysplasiaspondyloenchondrodysplasia (SPENCD) (1)
Infected (1)
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Plasmodium berghei CTRP knockout strain (Dessens et al., 1999) infection (1)
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Human immunodeficiency virus infectious disease (1)

Technology Type

Mass Spectrometry (6)
Shotgun proteomics (4)
Mass spectrometry assay (3)
Mass spectrometry (3)
Affinity purification coupled with mass spectrometry proteomics (3)

Instrument Platform

Illumina HiSeq 4000 (25)
Illumina NovaSeq 6000 (19)
Illumina HiSeq 2000 (8)
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TruSeq RNA Sample Preparation protocol (3)
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Agilent Micro Array Scanner G2565CA (2)
GenePix 4000B [Axon Instruments] (2)
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BD FACS Aria II (1)
Aspara® Smart Grower Hydroponic (1)
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- (1)
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Publication Date

2010 (64)
2015 (54)
2014 (46)
2016 (44)
2012 (43)
2013 (39)
2011 (33)
2009 (25)
2008 (23)
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2025 (16)
2024 (15)
2026 (12)
2018 (11)
2017 (11)
2007 (9)
2022 (8)
2020 (8)
2019 (8)
2006 (6)
2005 (3)

UNIPROT ID/AC

O75326 (1)
P10914 (1)
Q6ZMJ4 (1)
P20339 (1)
P49747 (1)
P35241 (1)
P27348 (1)
P07996 (1)
Q9NPH9 (1)
Q13568 (1)
Q5D1E8 (1)
Q8N884 (1)
O75131 (1)
O00220 (1)
Q8IUC6 (1)
P19876 (1)
Q9NP97 (1)
P54753 (1)
P08754 (1)
Q16548 (1)
O95760 (1)
Q92974 (1)
O95819 (1)
P24001 (1)
P02778 (1)
O43521 (1)
P17275 (1)
P01911 (1)
O43734 (1)
P35613 (1)

ENSEMBL ID

ENSG00000104432 (1)
ENSG00000168811 (1)
ENSG00000182866 (1)
ENSG00000125347 (1)
ENSG00000157368 (1)
ENSG00000169429 (1)
ENSG00000271503 (1)
ENSG00000106366 (1)
ENSG00000144566 (1)
ENSG00000044574 (1)
ENSG00000105664 (1)
ENSG00000137710 (1)
ENSG00000105974 (1)
ENSG00000006062 (1)
ENSG00000134308 (1)
ENSG00000284565 (1)
ENSG00000109458 (1)
ENSG00000197122 (1)
ENSG00000082701 (1)
ENSG00000124762 (1)
ENSG00000002330 (1)
ENSG00000081041 (1)
ENSG00000137801 (1)
ENSG00000102871 (1)
ENSG00000137693 (1)
ENSG00000065559 (1)
ENSG00000111536 (1)
ENSG00000145386 (1)
ENSG00000128604 (1)
ENSG00000284049 (1)

CHEBI ID

CHEBI:190628 (1)
CHEBI:91272 (1)
CHEBI:177632 (1)
CHEBI:182644 (1)
CHEBI:92163 (1)
CHEBI:192634 (1)
CHEBI:170032 (1)
CHEBI:181115 (1)
CHEBI:93118 (1)
CHEBI:192635 (1)
CHEBI:183494 (1)
CHEBI:181543 (1)
CHEBI:183866 (1)
CHEBI:183766 (1)
CHEBI:192584 (1)
CHEBI:182162 (1)
CHEBI:181001 (1)
CHEBI:183433 (1)
CHEBI:132234 (1)
CHEBI:190662 (1)
CHEBI:175830 (1)
CHEBI:183721 (1)
CHEBI:192661 (1)
CHEBI:183348 (1)
CHEBI:183779 (1)
CHEBI:192652 (1)
CHEBI:170034 (1)
CHEBI:183446 (1)
CHEBI:77995 (1)
CHEBI:190586 (1)

Metabolite Name

Isorhamnetin (2)
Benzoic acid (2)
Taurine (2)
Cholic acid (2)
2,3-Dinor-8-epi-prostaglandin F2alpha (1)
Alpha-,alpha-Trehalose (1)
Benzylsuccinic acid (1)
Dehydro-L-ascorbic acid (1)
N-[1-methyl-1-(2-phenyldiaz-1-enyl)ethyl]-N'-phenylthiourea (1)
Phenyl-beta-glucopyranoside (1)
2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one (1)
N-[4-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl]cyclohexanecarboxamide (1)
Prostaglandin F1beta (1)
[(2S,3R,4S,5S)-3-[(2S,3R,4R,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl] (4aS,6aS,6bR,10S,12aR,14bS)-10-[(2R,3R,4S,5S,6R)-4-hydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate_30.2% (1)
NCGC00025125-21!N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide [IIN-based on: CCMSLIB00000845970] (1)
NCGC00380698-01_C24H30O13_Cyclopenta[c]pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-4a-hydroxy-7-methyl-5-oxo-, 2-(3,4-dihydroxyphenyl)ethyl ester, (1S,4aR,7aR)- (1)
2-[4-[(3S,3aR,6S,6aR)-6-[3-methoxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol (1)
(G)(NAM)-AemA;(3s-4)-(G)(NAM)-AemA (1)
MMV676480 (1)
Flavone base + 3O, 2MeO, O-guaiacylglyceryl-Hex (1)
NCGC00347420-02_C39H65NO12_15-Hydroxyspirosolan-3-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside (1)
NCGC00381337-01_C64H104O30_Pentopyranosyl-(1->4)pentopyranosyl-(1->4)-1-O-[(3beta,5xi,9xi,18xi)-3-{[hexopyranosyl-(1->3)hexopyranosyl-(1->4)-6-deoxyhexopyranosyl]oxy}-28-oxoolean-12-en-28-yl]hexopyranose (1)
(7S,9E,11S,12R,13S,14S,15S,16R,17S,18S,19E,21Z)-26-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1,3,5(28),9,19,2... (1)
NCGC00380818-01_C17H15ClO6_7-Chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexa[2,5]diene]-3,4'-dione (1)
MGDG (18:3/18:4)_(2S)-1-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(6Z,9Z,12Z,15Z-octa-decatetranoyl)-3-beta-D-galacto-pyranosyl-sn-glycerol (1)
(NAG)(NAM)-AeKA[3-NH2-GGGG] (1)
NCGC00347534-02![2-[4-hydroxy-2,5-bis(hydroxymethyl)-3-(2-methylpropanoyloxy)oxolan-2-yl]oxy-6-(hydroxymethyl)-4,5-bis(2-methylpropanoyloxy)oxan-3-yl] decanoate [IIN-based on: CCMSLIB00000848581] (1)
Methyl 2-(3,5-dichloro-2-hydroxy-6-methoxy-4-methylbenzoyl)-3,5-dihydroxybenzoate (1)
Pesticide3_Chlorfluazuron_C20H9Cl3F5N3O3_Benzamide, N-[[[3,5-dichloro-4-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]amino]carbonyl]-2,6-difluoro- (1)
NCGC00385692-01_C44H68O14_3-Hydroxyspirosta-5,25(27)-dien-1-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-(2-hydroxy-3-methylpentanoyl)-alpha-L-arabinopyranoside (1)

IsPrivate

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First Public Date

2014 (10)
2024 (8)
2015 (8)
2026 (7)
2023 (5)
2025 (4)
2018 (4)
2021 (3)
2017 (3)
2020 (2)
2013 (2)
2016 (1)

Modelling Approach

Logical model (1)

Study type

Transcription profiling by array (301)
RNA-seq of coding RNA (77)
Other (14)
ChIP-seq (8)
Unknown experiment type (7)
Animal - High-throughput sequencing (7)
DNA-seq (4)
RNA-seq of coding RNA from single cells (4)
RNA-seq of non coding RNA (4)
Cell line - High-throughput sequencing (3)
CLIP-seq (3)
Comparative genomic hybridization by array (3)
RIP-seq (3)
MicroRNA profiling by high throughput sequencing (2)
ATAC-seq (2)
Methylation profiling by high throughput sequencing (2)
Translation profiling (1)
High-throughput sequencing (1)
Proteomic profiling by mass spectrometer (1)
Transcription profiling by tiling array (1)
ChIP-chip by array (1)
Ribo-seq (1)
Methylation profiling by array (1)

Release Date

2010 (80)
2015 (73)
2016 (67)
2014 (65)
2021 (59)
2012 (57)
2013 (53)
2022 (46)
2011 (46)
2023 (40)
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2017 (39)
2009 (34)
2020 (32)
2008 (32)
2024 (28)
2018 (26)
2019 (24)
2007 (15)
2006 (13)
2026 (11)
2005 (6)
2004 (3)
2003 (2)
2000 (2)
1999 (2)
1998 (2)
1997 (1)

Lab affiliation

Assistant Professor at Biomolecular Mass Spectrometry and Proteomics, Utrecht University Proteomics facility anager at Netherlands Cancer Institute (1)
Experimental Systems Immunology, Max-Planck Institute of Biochemistry, Martinsried, Germany (1)
MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, University of Dundee, United Kingdom (1)
UCSF, San Francisco, CA (1)
VIB-UGent Center for Medical Biotechnology, Belgium Department of Biochemistry, Ghent University, Belgium (1)
Wuhan Institute of Virology, Chinese Academy of Sciences (1)

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RNA-seq of mice TRAF2/Casp-8LPC-KO tumors

This model was used to study the relationship between NF-kB and PCD regulation and generated mice with combined conditional ablation of Traf2 and Caspase-8 (TRAF2/Casp-8LPC-KO) in order to block apoptosis and specifically study the role of necroptosis in Traf2-deficient hepatocytes in vivo.

ORGANISM(S): Mus musculus

2019-05-31 | E-MTAB-4598 | biostudies-arrayexpress

Prognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [copy number analysis]

Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...

ORGANISM(S): Homo sapiens

2015-11-21 | E-GEOD-64257 | biostudies-arrayexpress

Transcription profiling of mouse lymph node derived B cells from Traf2 and Traf3 B cell knockout mice and Baff tg mice

Tumor necrosis factor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a co-operative and non-redundant manner to suppress nuclear factor-ÎºB2 (NF-ÎºB2) activation, gene expression and survival in mature B cells. In the absence of this suppressive activity, B cells developed in...

ORGANISM(S): Mus musculus

2008-04-07 | E-GEOD-10422 | biostudies-arrayexpress

Prognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [gene expression]

ORGANISM(S): Homo sapiens

2015-11-21 | E-GEOD-64256 | biostudies-arrayexpress

RNA-seq of mice TRAF2/Casp-8LPC-KO tumors

PRJEB13162 | ENA

Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2–FASN axis [RNA-Seq TRAF2-KD]

PRJNA1416779 | ENA

Prognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

2015-11-21 | E-GEOD-64258 | biostudies-arrayexpress

Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.

Not available

S-EPMC2855162 | biostudies-literature

TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination.

Not available

S-EPMC1142588 | biostudies-literature

Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2–FASN axis [RNA-Seq TRAF2-KD]

Lipid metabolism plays a critical role in the progression of cancers, including glioblastoma (GBM). Tumor necrosis factor-α (TNF-α) exhibits a dual role in the tumor microenvironment: at high concentrations, it induces cell death and exerts anti-tumor effects, while at low doses, it demonstrates pro...

ORGANISM(S): Homo sapiens

2026-02-04 | GSE318134 | GEO

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