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TranscriptomicsDNA methylation analysis of porcine mammary epithelial cells challenged with Escherichia coli
Epigenetic changes such as DNA methylations regulate gene expression patterns in response to environmental cues including infections. Microbial infections induced DNA methylation may play a potential role in modulating host-immune response. In the present study, we sought to determine DNA methylatio...
ORGANISM(S): Sus scrofa 
2019-07-17 | E-MTAB-7363 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of the amygdala, hippocampus, hypothalamus and adrenal gland of the pig using Reduced Representation Bisulfite Sequencing (RRBS)
Three brain regions of the limbic system, the amygdala, hippocampus and hypothalamus, are responsible for survival behaviors such as feeding and physical challenging. Hypothalamus works together with pituitary and adrenal gland (HPA-axis) to adjust homeostatic state by modulating stress-response hor...
ORGANISM(S): Sus scrofa 
2024-11-19 | E-MTAB-10640 | biostudies-arrayexpress
TranscriptomicsA comparative mRNA-seq profiling of the liver, rumen villi, mammalian gland and kidney of Holstein dairy cows with high vs normal milk-urea excretion and with low vs normal (control) crude protein intake
Nitrogen (N) emissions became a huge topic under environmental and nutrient concerns in dairy farming. Nitrogen is metabolized in cows as a consequence of feed crude protein digestion which is either recycled or excreted via urine, faeces and/or milk. In dairy cows differences between cows in N-recy...
ORGANISM(S): Bos taurus 
2024-11-30 | E-MTAB-9901 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles (RRBS) of the muscle of pigs distinct in metabolic types and genetic background
DNA methylation is an epigenetic mechanism that plays roles in gene regulation and expression. This study aims to profile DNA methylation at genome-wide scale and single base resolution using reduced representation bisulfite sequencing (RRBS) of the muscle of pigs differing in muscle metabolism and ...
ORGANISM(S): Sus scrofa 
2024-12-01 | E-MTAB-7338 | biostudies-arrayexpress
TranscriptomicsFunctional Study of the Chicken microRNAs miR-143 and miR-10a
MicroRNA (miRNA) is a family of small regulatory RNA that post-transcriptionally regulates many biological functions including growth and development. Chicken miR-143 and miR-10a are expressed in both the embryonic and post-hatch chick in a spatio-temporal manner. In order to study the functions of ...
ORGANISM(S): Gallus gallus 
2010-05-16 | E-GEOD-16653 | biostudies-arrayexpress
TranscriptomicsTranscriptome responses to dexamethasone of the hypothalamus of pigs with different genotypes at the GRAla610Val mutation
The main aims of the experiment were to 1) chart gene networks governed by glucocorticoid receptor on a genome-wide scale, 2) to provide insights into mechanisms modulating glucocorticoid sensitivity and 3) to obtain better understanding of molecular and phenotypic consequences of the GRAla610Val su...
ORGANISM(S): Sus scrofa 
2021-11-30 | E-MTAB-7494 | biostudies-arrayexpress
TranscriptomicsTransriptome responses to dexamethasone in hippocampus of pigs with different genotypes at a glucocorticoid receptor gain-of-function mutation profiled using RNA-Seq
The main aims of the experiment were to 1) chart gene networks governed by glucocorticoid receptor on a genome-wide scale, 2) to provide insights into mechanisms modulating glucocorticoid sensitivity and 3) to obtain better understanding of molecular and phenotypic consequences of the GRAla610Val su...
ORGANISM(S): Sus scrofa 
2021-12-31 | E-MTAB-9098 | biostudies-arrayexpress
TranscriptomicsExpression profiles of parathyroid glands from healthy pigs challenged by fetal and postnatal dietary interventions
Calcium (Ca) and phosphorus (P) are essential micronutrients that are linked to a wide set of biological processes. A deeper understanding of the molecular mechanisms of Ca- and P-utilization in sows and their offspring could help to reduce the environmental impact. Parathyroid glands play an import...
ORGANISM(S): Sus scrofa 
2024-11-30 | E-MTAB-9768 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the mouse myoblasts cell line C2C12 cultured in four temperature-treatment conditions
This experiment aims at investigating the effects of heat-stress on transcriptomic changes of the muscle cells in in-vitro model using the mouse myoblast cell line C2C12. Four incubation temperatures were set as a treatment condition at 35°C (cold stress), 37°C (control), 39°C (mild heat stress) and...
ORGANISM(S): Mus musculus 
2024-11-30 | E-MTAB-9895 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling (RRBS) of differentiating porcine synovial mesenchymal stem cells (PSMSCs) during the course of osteogenic induction
This study aims to investigate DNA methylation of differentiating synovial mesenchymal stem cells (psMSCs) isolated from German Landrace (DL) and Angeln Saddleback (AS) pigs previously characterized and described (Siengdee et al 2020, Frontiers in Cell and Developmental Biology). The 3rd passage of ...
ORGANISM(S): Sus scrofa 
2024-12-01 | E-MTAB-9913 | biostudies-arrayexpress
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