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GenomicsCRISPR-Cas9 screening of lncRNAs and protein coding genes involved in the transdifferentiation from human pre-B cells into macrophages
BLaER1 cells are human leukemia pre-B cells able to transdifferentiate into functional and non-tumorigenic macrophages. With the goal of uncovering the genes involved in the transdifferentiation process, we have designed a DECKO (Double Excision CRISPR Knockout) library to knockout lncRNAs and prote...
ORGANISM(S): Homo sapiens 
2022-04-25 | E-MTAB-10445 | biostudies-arrayexpress
GenomicsComparative transcriptomics of B cell transdifferentiation in human and mouse. ChIP-Seq data
Exogenous overexpression of CEBPA transcription factor induces transdifferentiation from pro B cells into functional macrophages. Here we report the CEBPA binding ChIP-Seq data at 12 hours time point after induction of transdifferentiation in human BLaER1 cells (Rapino et al. 2013).
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-7114 | biostudies-arrayexpress
ModelsCollombet2016 - Lymphoid and myeloid cell specification and transdifferentiation
Collombet2016 - Lymphoid and myeloid cell specification and transdifferentiation This model is described in the article: Logical modeling of lymphoid and myeloid cell specification and transdifferentiation Samuel Collombet, Chris van Oevelen, Jose Luis Sardina Ortega, Wassim Abo...
2017-06-08 | MODEL1610240000 | BioModels
TranscriptomicsRNA-Seq data - Comparative transcriptomics of B cell transdifferentiation in human and mouse
Exogenous overexpression of CEBPA transcription factor induces transdifferentiation from pro B cells into functional macrophages. Here we analyzed the gene expression along transdifferentiation process in human and mouse. Following the original reports (Bussmann et al. 2009; Rapino et al. 2013), hum...
ORGANISM(S): Mus musculus 
2022-01-01 | E-MTAB-7115 | biostudies-arrayexpress
TranscriptomicsHistone modifications along transdifferentiation from B cell to macrophage
Transdifferentiation of BLaER1 B cell into macrophages is an appropriate model to understand how chromatin behaves along a dynamic process. With this purpose, we have performed chromatin immunoprecipitation experiments of two histone modifications associated to active enhancer activity along 4 time ...
ORGANISM(S): Homo sapiens 
2020-05-08 | E-MTAB-9010 | biostudies-arrayexpress
GenomicsEpigenetic analysis of BlaER1 transdifferentiation
Epigenetic analysis of BlaER1 transdifferentiation
PRJNA549264 | ENA
TranscriptomicsTranscriptomic profiling of human BLaER1 pre-B cells transdifferentiation into macrophages
BLaER1 is a human B cell precursor leukemia cell line derived from the RCH-ACV cells. These cells are stably infected with a construct that overexpresses the transcription factor C/EBPa fused with the estrogen receptor hormone binding domain (ER) and GFP. Upon induction with beta-estradiol, C/EBP is...
ORGANISM(S): Homo sapiens 
2022-05-31 | E-MTAB-9790 | biostudies-arrayexpress
UnknownLogical modeling of lymphoid and myeloid cell specification and transdifferentiation.
Not available
S-EPMC5468615 | biostudies-literature
GenomicsChip-seq of BlaER1 B cell transdifferentiation
Chip-seq of BlaER1 B cell transdifferentiation
PRJEB28056 | ENA
GenomicsRNA variant assessment using transactivation and transdifferentiation
RNA variant assessment using transactivation and transdifferentiation
PRJNA1139201 | ENA
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