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TranscriptomicsAffymetrix SNP array data for xenografted transient abnormal myelopoiesis samples
Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder that progresses to myeloid leukemia of Down syndrome (ML-DS) through the accumulation of genetic alterations. To investigate the mechanism of leukemogenesis in this disorder, a xenograft model of TAM was established using NOD/Sh...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-44739 | biostudies-arrayexpress
TranscriptomicsMultiplexed DNA high throughput genotyping study to determine the mutational status of transient (TAM) and acute myeloid leukaemic (ML-DS) Down syndrome individuals.
We used a 48.48 Fluidigm Access Array approach (1070 Amplicons spanning 62 genes: 157kB coverage) of genomic DNA from over 100 samples to genotype individuals with transient abnormal myelopoiesis (TAM) and acute myeloid leukemia of Down syndrome (ML-DS). Individually barcoded patient samples were ...
ORGANISM(S): Homo sapiens 
2019-07-17 | E-MTAB-7729 | biostudies-arrayexpress
TranscriptomicsGATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia
Transient leukemia (TL) is evident in 5-10% of all neonates with Down syndrome (DS) and associated with N-terminal truncating GATA1-mutations (GATA1s). Here we analyzed the effect of on gene expression upon ectopic expression of Gata1s or Gata1, while simultaneously knocking down endogenous GATA1,...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-56332 | biostudies-arrayexpress
GenomicsAffymetrix SNP array data for xenografted transient abnormal myelopoiesis samples
Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder that progresses to myeloid leukemia of Down syndrome (ML-DS) through the accumulation of genetic alterations. To investigate the mechanism of leukemogenesis in this disorder, a xenograft model of TAM was established using NOD/Sh...
ORGANISM(S): Homo sapiens 
2013-03-01 | GSE44739 | GEO
UnknownTwo Novel GATA1 Mutations in Transient Abnormal Myelopoiesis of Thai Neonates with Down Syndrome.
Not available
S-EPMC6824893 | biostudies-literature
UnknownModeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology.
Not available
S-EPMC7558799 | biostudies-literature
GenomicsHomo sapiens
Affymetrix SNP array data for xenografted transient abnormal myelopoiesis samples
PRJNA191153 | ENA
UnknownPrenatal diagnosis of Down syndrome combined with transient abnormal myelopoiesis in foetuses with a GATA1 gene variant: two case reports.
Not available
S-EPMC10588144 | biostudies-literature
GenomicsPathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression
Pathologic TPO-induced TPOR-CSF2RB signaling mediates Down syndrome abnormal myelopoiesis due to GATA1 mutant-dependent CSF2RB overexpression
PRJNA1271516 | ENA
UnknownCytokine profiling in 128 patients with transient abnormal myelopoiesis: a report from the JPLSG TAM-10 trial.
Not available
S-EPMC11222942 | biostudies-literature
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