Translation optimization

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Optimization of codon translation rates via tRNA modifications maintains proteome integrity

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...

ORGANISM(S): Caenorhabditis elegans

2015-06-04 | E-GEOD-67387 | biostudies-arrayexpress

Optimization of codon translation rates via tRNA modifications maintains proteome integrity

PRJNA279785 | ENA

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

PRJNA723762 | ENA

Optimization of speed and accuracy of decoding in translation.

Not available

S-EPMC2982755 | biostudies-literature

Genome-wide impact of codon usage bias on translation optimization in Drosophila melanogaster.

Not available

S-EPMC11437122 | biostudies-literature

Direction matters: Comparing post-editing and human translation effort and quality.

Not available

S-EPMC12306749 | biostudies-literature

Codon usage optimization in pluripotent embryonic stem cells [tRNA sequencing]

PRJNA509375 | ENA

Codon usage optimization in pluripotent embryonic stem cells [RNA-seq]

PRJNA439265 | ENA

Kong2022 - Conditional Antibody Design as 3D Equivariant Graph Translation

Multi-channel Equivariant Attention Network (MEAN) to co-design 1D sequences and 3D structures of CDRs. To be specific, MEAN formulates antibody design as a conditional graph translation problem by importing extra components including the target antigen and the light chain of the antibody. Then, MEA...

2023-05-10 | BIOMD0000001070 | BioModels

Machine Learning Model FAIR-AIML

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.

Not available

S-EPMC4380071 | biostudies-literature

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