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TranscriptomicsThe human mitochondrial transcriptome
The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, tRNAs and rRNAs. Here we provide a comprehensive analysis of the human mitochondrial transcriptome across multiple cell li...
ORGANISM(S): Homo sapiens 
2011-07-20 | E-GEOD-30772 | biostudies-arrayexpress
ProteomicsUSP16 Regulates Mitochondrial Function by Deubiquitinating TOM40, A Core Component of the Translocase in Mitochondrial Outer Membrane_AP-MS
The ubiquitin-specific protease 16 (USP16), initially identified as a histone H2A-specific deubiquitinase. However, whether endogenous USP16 localizes to mitochondria and, if so, how it regulates mitochondrial function remain unclear. Therefore, this study focused on USP16, systematically investigat...
ORGANISM(S): Homo Sapiens 
PXD065823 |
UnknownStructural overview of the translocase of the mitochondrial outer membrane complex.
Not available
S-EPMC9260164 | biostudies-literature
ProteomicsAn Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes (SILAC-IP data)
The AAA-ATPase Msp1 extracts mislocalized outer membrane proteins and thus contributes to mitochondrial proteostasis. Using pull down experiments, we show that trypanosomal Msp1 localizes to both the glycosome and the mitochondrial outer membrane, where it forms a stable complex with four outer memb...
ORGANISM(S): Trypanosoma brucei 
2023-07-26 | PXD039631 | Pride
Trypanosoma brucei Proteomics Co-immunoprecipitation Silac Mitochondrial quality control 
ProteomicsAn Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of trypanosomes (RNAi knockdown data)
The AAA-ATPase Msp1 extracts mislocalized outer membrane proteins and thus contributes to mitochondrial proteostasis. Using pull down experiments, we show that trypanosomal Msp1 localizes to both the glycosome and the mitochondrial outer membrane, where it forms a stable complex with four outer memb...
ORGANISM(S): Trypanosoma brucei 
2023-07-26 | PXD039634 | Pride
Trypanosoma brucei Proteomics Peptide stable isotope dimethyl labeling Mitochondrial quality control Rnai-mediated protein knockdown 
UnknownMitochondrial-derived compartments remove surplus proteins from the outer mitochondrial membrane.
Not available
S-EPMC11320589 | biostudies-literature
UnknownEvidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40.
Not available
S-EPMC4646270 | biostudies-literature
ProteomicsPINK1-TOM-TIM23 complex SDA XL-MS
3xFLAG-tagged human wild-type PINK1 was expressed and immunoprecipitated with anti-FLAG beads. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by in solution trypsin digestion and MS analysis.
ORGANISM(S): Homo Sapiens (human) 
2025-05-29 | PXD058526 | JPOST Repository
UnknownStructure of the intact Tom20 receptor in the human translocase of the outer membrane complex.
Not available
S-EPMC11273160 | biostudies-literature
TranscriptomicsASFV array analysis
African swine fever virus (ASFV) produces a fatal acute hemorrhagic fever in domesticated pigs that potentially is a worldwide economic threat. Using an expressed sequence tag (EST) library-based antisense method of random gene inactivation and a phenotypic screen for limitation of ASFV replication ...
ORGANISM(S): Homo sapiens 
2007-08-09 | E-GEOD-7581 | biostudies-arrayexpress
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