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MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
MetabolomicsMolecular basis for multidrug efflux by an anaerobic-associated RND transporter

Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

2025-09-26 | MTBLS13050 | MetaboLights
MetabolomicsThe suberin transporter StABCG1 is required for barrier formation in potato leaves

Suberin is a hydrophobic biopolymer that acts as an internal and external diffusion and transpiration barrier in plants. It is involved in two phases of wound healing, i.e. initial closing layer formation and subsequent wound periderm development. Transcriptomic and metabolomic analyses of wounde...

2024-09-19 | MTBLS4823 | MetaboLights
MetabolomicsA female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametoc...
2016-09-14 | MTBLS98 | MetaboLights
MetabolomicsRuegeria pomeroyi transporter mutant substrate drawdown
Not available
ORGANISM(S): Ruegeria pomeroyi 
ST002381 | MetabolomicsWorkbench
MetabolomicsDevelopment of a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var to target glutamine dependency in cancer

The mitochondrial glutamine transporter SLC1A5_var plays a central role in the metabolic reprogramming of cancer cells by facilitating glutamine import into mitochondria for energy production and redox homeostasis. Despite its critical function, the development of effective and selective inhibito...

2025-08-13 | MTBLS12852 | MetaboLights
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Not available
ORGANISM(S): Homo sapiens 
ST001730 | MetabolomicsWorkbench
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance (part-III)
Not available
ORGANISM(S): Homo sapiens 
ST001732 | MetabolomicsWorkbench
MetabolomicsMitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001731 | MetabolomicsWorkbench
TranscriptomicsTranscriptional profiling of orf19.5100/MLT1 ABC transporter knockout in Candida albicans
Recent reports have been suggested involvement of ABC transporters in various physiological roles.To get better insight about possible involvement of vacuolar ABC transporter MLT1/orf19.5100 in different physiological roles transcriptional profiling have been peformed and compared between WT(SC5314...
ORGANISM(S): Candida albicans 
2016-07-25 | E-GEOD-70341 | biostudies-arrayexpress
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