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TranscriptomicsThe genetics of wound healing in tympanic membranes in rats
The aim of this study was to identify the genes differentially expressed between timepoints in the week following tympanic membrane perforation in rats. Tissue from 240 individual rats was used in this study following random allocation into timepoint groups to be sacrificed over 7 days. An Agilent o...
ORGANISM(S): Rattus norvegicus 
2010-08-18 | E-GEOD-17698 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Human Umbilical Vein Endothelial Cells (HUVEC) after treatment with Erg or control antisense (GeneBloc)
The endothelial transcription factor Erg (Ets Related Gene) plays an important role in homeostasis and angiogenesis by regulating many endothelial functions including survival and junction stability. Here we show that Erg regulates endothelial cell migration. Transcriptome profiling of Erg-deficient...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-32984 | biostudies-arrayexpress
TranscriptomicsPrimary human erythroid progenitor cells SAHA treatment samples
Gene expression profiling was performed on primary human erythroid progenitor cells left untreated or treated with 0.5uM SAHA. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a valida...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22367 | biostudies-arrayexpress
UnknownComparative risk of pulmonary adverse events with transfusion of pathogen reduced and conventional platelet components.
Not available
S-EPMC9544211 | biostudies-literature
TranscriptomicsFolsomia candida exposed to soil containing different phenanthrene concentrations
Polycyclic aromatic hydrocarbons are common pollutants in soil, have negative effects on soil ecosystems, and are potentially carcinogenic. The Springtail (Collembola) Folsomia candida is often used as an indicator species for soil toxicity. Here we report a toxicogenomic study that translates the e...
ORGANISM(S): Folsomia candida 
2010-05-18 | E-GEOD-14207 | biostudies-arrayexpress
TranscriptomicsA small molecule accelerates neuronal differentiation in the adult rat
Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain.However, little is known about the molecular mechanisms regulating hippocampal neural progenitor cells (NPCs) and whether their fate can be pharmacologically modulated to improve neural plasti...
ORGANISM(S): Rattus norvegicus 
2010-08-18 | E-GEOD-23668 | biostudies-arrayexpress
TranscriptomicsMusashi 2 regulates normal hematopoiesis and accelerates leukemogenesis (Leukemia cell lines)
We demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSC), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of Msi2 in a mouse model increases HSC cell cycle progression and cooperates with BCR-ABL1 to induce an aggressiv...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-22775 | biostudies-arrayexpress
TranscriptomicsThe Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS
Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS) suggesting that haploinsufficie...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-20352 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the impact of environmental perturbation on cis-regulation of gene expression: BMP2, 2hr
Genetic variants altering cis-regulation of normal gene expression (cis-eQTLs) have been extensively mapped in human cells and tissues, but the extent to which environmental perturbation influences such traits has not been studied to date. We carried out large-scale induction experiments using prima...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-21410 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the impact of environmental perturbation on cis-regulation of gene expression: DEX, 24hr
Genetic variants altering cis-regulation of normal gene expression (cis-eQTLs) have been extensively mapped in human cells and tissues, but the extent to which environmental perturbation influences such traits has not been studied to date. We carried out large-scale induction experiments using prima...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-21725 | biostudies-arrayexpress
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