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MetabolomicsMetabolic Biomarkers of Treatment-Resistant Schizophrenia and Cognitive Correlates: Insights from a Machine Learning

Metabolic Biomarkers of Treatment-Resistant Schizophrenia and Cognitive Correlates: Insights from a Machine Learning

2027-02-05 | MTBLS14005 | MetaboLights
MetabolomicsA statistical analysis of the effects of urease pre-treatment on the measurement of the urinary metabolome by gas chromatography–mass spectrometry
Urease pre-treatment of urine has been utilized since the early 1960s to remove high levels of urea from samples prior to further processing and analysis by gas chromatography–mass spectrometry (GC–MS). Aside from the obvious depletion or elimination of urea, the effect, if any, of urease pre-treatm...
2014-05-21 | MTBLS71 | MetaboLights
MetabolomicsUntargeted 1 H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant Schizophrenia patients: a pilot study

Schizophrenia is a severe psychiatric disorder impacting roughly 1% of individuals. The effectiveness of antipsychotic therapy greatly varies, with around 30% of patients categorised as treatment-resistant (TRS). TRS is characterised by a lack of response to at least two clinical trials invo...

2025-10-01 | MTBLS12709 | MetaboLights
MetabolomicsGC-MS based targeted metabolic profiling identifies changes in the wheat metabolome following deoxynivalenol treatment
Fusarium graminearum and related species commonly infest grains causing the devastating plant disease Fusarium head blight (FHB) and the formation of trichothecene mycotoxins. The most relevant toxin is deoxynivalenol (DON), which acts as a virulence factor of the pathogen. FHB is difficult to contr...
2014-10-17 | MTBLS112 | MetaboLights
MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
MetabolomicsPlasma metabolomic and lipidomic signatures characteristic of treatment non-response in rheumatoid arthritis

Objectives: This study aimed to investigate plasma metabolomic and lipidomic profiles in rheumatoid arthritis (RA) to identify potential biomarkers for distinguishing treatment responses.

Methods: Plasma samples w...

2026-06-02 | MTBLS13238 | MetaboLights
MetabolomicsMetabolomic Profiling Following Sin A Treatment

Schisantherin A, a natural product, safely alleviates obesity and associated metabolic disorders by orchestrating crosstalk among immune, neuronal, adipose cells, metabolic organs, and gut bacteria via increased circulating conjugated bile acids.

2025-11-21 | MTBLS13266 | MetaboLights
MetabolomicsHyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment

Introduction

Hyperhomocysteinemia (HHCys) is an independent risk factor for various diseases such as cardiovascular diseases, Alzheimer's, and cancers. Folate deficiency is one of the significant reasons for HHCys. However, it is not known whether folate deficiency with HHCys is associated w...
2022-02-07 | MTBLS2150 | MetaboLights
MetabolomicsStudy on the Changes of Fecal Lipid Metabolites in Thyroid Cancer Patients Before and After Treatment

Study on the Changes of Fecal Lipid Metabolites in Thyroid Cancer Patients Before and After Treatment

2025-07-25 | MTBLS12769 | MetaboLights
MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
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