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TranscriptomicsPRONOUNCED PHENOTYPE IN ACTIVATED TREG CELLS DURING A CHRONIC HELMINTH INFECTION
Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic he...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-17580 | biostudies-arrayexpress
TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
UnknownClinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation.
Not available
S-EPMC2522271 | biostudies-literature
TranscriptomicsAnalysis of tumour gene expression from fibrosarcoma mouse model following Treg depletion
Experiment was designed to look at the differences in gene expression between mice which responded to Treg depletion and began to control tumour growth, mice which could not bring tumour growth under control, untreated mice and a lymp node comparison.
ORGANISM(S): Mus musculus 
2020-07-31 | E-MTAB-9351 | biostudies-arrayexpress
GenomicsAn intersectional genetic cell depletion unravels the unique role of Th1-Treg cells in tumor immunity
An intersectional genetic cell depletion unravels the unique role of Th1-Treg cells in tumor immunity
PRJNA811448 | ENA
GenomicsAcquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [scRNA-seq]
Acquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [scRNA-seq]
PRJNA992495 | ENA
GenomicsAcquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [RNA-seq]
Acquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [RNA-seq]
PRJNA992496 | ENA
TranscriptomicsMicroarray of whole brain gene expression in transgenic adult female mice expressing primate diphtheria toxin receptor under Foxp3 promoter (Foxp3DTR) treated with either diphtheria toxin or vehicle
Peripheral regulatory T-cell (Treg) levels correlate with psychiatric outcomes in humans, and Treg-depletion induced by diptheria toxin administration in Foxp3DTR knock-in mice results in specific behaviour phenotypes. We examined the consequences of Treg depletion on whole brain gene expression i...
ORGANISM(S): Mus musculus 
2026-07-01 | E-MTAB-16677 | biostudies-arrayexpress
GenomicsAcquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [RNA-seq II]
Acquisition of suppressive function by CD4+ conventional T cells limits anti-tumor immunity driven by Treg depletion [RNA-seq II]
PRJNA994054 | ENA
UnknownRapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity.
Not available
S-EPMC4106855 | biostudies-literature
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