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The aim of the project is to do proteomic analysis of total cell lysate from rest and activated mouse Tregs. The proteomic data were mapped to the Gene Ontology Cellular Component (GOCC)database to obtain the list of membrane proteins on activated Tregs. The set of membrane proteins identified were ...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-28 | PXD022259 | Pride
ATAC-seq data from naïve Tregs, memory Tregs and CD161+ Tregs
Disturbed expression of microRNAs (miRNAs) in regulatory T-cells (Tregs) leads to development of autoimmunity in experimental mouse models. However, the miRNA expression signature characterizing Tregs of autoimmune diseases, such as rheumatoid arthritis (RA) has not been determined yet. Moreover, th...
ORGANISM(S): Homo sapiens 
Transcriptome analysis of naïve Tregs, memory Tregs and CD161+ Tregs
RNA-seq of Tregs
The objective of this study was to determine if a subset of regulatory T cells (Tregs) expressing the transcription factor, Zbtb20, played a unique role in the function of the immune system. Genetic reporter mice were used to isolate Zbtb20-expressing Tregs as well as activated (CD62Llo) and naive (...
ORGANISM(S): Mus musculus 
The adenosine 2A receptor (A2AR) is expressed on regulatory T cells (Tregs), but the functional significance is currently unknown. We compared the gene expression between wild-type (WT) and A2AR knockout (KO) Tregs and between WT Tregs treated with vehicle or a selective A2AR agonist. FACS-sorted G...
ORGANISM(S): Mus musculus 
Tregs deltaDC mice vs. wt mice
Characterization of mature Tregs in the thymus
This experiment compare the transcriptional profile of CD8+CD45RClow Tregs from naive untreated rats compared to CD40Ig-treated tolerant allograft recipients.
ORGANISM(S): Rattus norvegicus 
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