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ProteomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Here we map the molecular response of a synthetic community of 32 human gut bacteria to three non-antibiotic drugs by using five omics layers, namely 16S rRNA gene profiling, metagenomics, metatranscriptomics, metaproteomics, and metabolomics. Using this controlled setting, we find that all omics me...
ORGANISM(S): metagenome 
2022-12-13 | PXD036445 | Pride
Multi-omics proteomics metagenomics metatranscriptomics community drug chlorpromazine niclosamide metformin gut microbiome microbiota 
ProteomicsThe Proteome Landscape of the Kingdoms of Life
Proteins preform the vast majority of functions in all biological domains but their large-scale investigation has lagged behind for technological reasons. Since the first essentially complete eukaryotic proteome was reported1, advances in mass spectrometry (MS)-based proteomics2 have enabled increas...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-13 | MSV000085728 | MassIVE
ProteomicsThe Proteome Landscape of the Kingdoms of Life
Proteins preform the vast majority of functions in all biological domains but their large-scale investigation has lagged behind for technological reasons. Since the first essentially complete eukaryotic proteome was reported1, advances in mass spectrometry (MS)-based proteomics2 have enabled increas...
ORGANISM(S): Dictyostelium Discoideum (ncbitaxon:44689) Triticum Aestivum (ncbitaxon:4565) Escherichia Coli (ncbitaxon:562) Sus Scrofa Domesticus (ncbitaxon:9825) Gallus Gallus (ncbitaxon:9031) Rattus Norvegicus (ncbitaxon:10116) Homo Sapiens (ncbitaxon:9606) Danio Rerio (ncbitaxon:7955) Saccharomyces Cerevisiae (ncbitaxon:4932) Bos Taurus (ncbitaxon:9913) Drosophila Melanogaster (ncbitaxon:7227) Arabidopsis Thaliana (ncbitaxon:3702) Vitis Vinifera (ncbitaxon:29760) Mus Musculus (ncbitaxon:10090) Caenorhabditis Elegans (ncbitaxon:6239) 
2020-07-10 | MSV000085716 | MassIVE
MetabolomicsConsistency across multi-omics layers in a drug-perturbed gut microbial community
Multi-omics analyses are increasingly employed in microbiome studies to obtain a holistic view of molecular changes occurring within microbial communities exposed to different conditions. However, it is not always clear to what extent each omics data type contributes to our understanding of the comm...
2022-12-08 | MTBLS3129 | MetaboLights
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084332 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084333 | MassIVE
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084344 | MassIVE
ProteomicsA.profundus DSM 5631 - Whole organism, SC (Muelleretal,nature2020)
abundance based on Spectral counting, Interaction consistency score: 9.1, Coverage: 60
ORGANISM(S): 572546 
2020-00-00 | 3739983960 | PAXDB
ProteomicsF.nucleatum ATCC 25586 - Whole organism, SC (Muelleretal,nature2020)
abundance based on Spectral counting, Interaction consistency score: 10.5, Coverage: 69
ORGANISM(S): 190304 
2020-00-00 | 138794487 | PAXDB
ProteomicsD.acetiphilus DSM 12809 - Whole organism, SC (Muelleretal,nature2020)
abundance based on Spectral counting, Interaction consistency score: 10.5, Coverage: 31
ORGANISM(S): 522772 
2020-00-00 | 1129373649 | PAXDB
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