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TranscriptomicsUpper airway gene expression is an effective surrogate biomarker for Th2-driven inflammation in the lower airway
Molecular profiling studies in asthma cohorts have identified a Th2-driven asthma subtype, characterized by elevated lower airway expression of POSTN, CLCA1 and SERPINB2. To assess upper airway gene expression as a potential biomarker for lower airway Th2 inflammation, we assayed upper airway (nasal...
ORGANISM(S): Homo sapiens 
2015-10-23 | E-GEOD-41861 | biostudies-arrayexpress
TranscriptomicsBlockade of thymic stromal lymphopoietin receptor (TSLPR) reduces allergic inflammation in a cynomolgus monkey model of asthma
TSLP pathway blockade is a potential strategy for asthma treatment, as TSLP modulates cytokine production by mast cells and regulates the activation of dendritic cells (DCs), which prime the differentiation of naM-CM-/ve T cells into inflammatory Th2 cells. To assess the effect of TSLPR blockade on ...
ORGANISM(S): Macaca fascicularis 
2013-10-22 | E-GEOD-41329 | biostudies-arrayexpress
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