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TranscriptomicsATF3 is a positive regulator of human IFN gene expression
The aim of this study was to identify genes regulated by IL-12, IL-18 and IFN-alpha during early differentiation of human Th1 cells Human cord blood CD4+ T cells were activated via TCR and cultured in the presence of IL-12, IFN-alpha or IL-12+IL-18. Cytokine induced gene expression was compared to a...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-20198 | biostudies-arrayexpress
GenomicsGenome-wide detection of STAT3 binding sites in human Th17 cells
STAT3 is a major transcription factor driving the polarization of Th17 cells in response to IL-6, TGF-β and IL1-β. STAT3 is phosphorylated and forms a homodimer and translocates into the nucleus. There STAT3 binds to specific DNA sequences, regulating the transcription of its target genes. Here we...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-67183 | biostudies-arrayexpress
TranscriptomicsGenome wide STAT3 RNAi expression profiling data from Thp,Th0 and Th17 cells
STAT3 is an immidiate regulator of Th17 differentiation. STAT3 difieciency downmodulate Th17 specific genes and Th17 responses. Therefore, we intend to identify genome wide targets of STAT3. We used microarrays to profile gene expression of STAT3 regulated genes during Th17 polarization. Total RNA w...
ORGANISM(S): Homo sapiens 
2017-05-03 | E-GEOD-67185 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (BeadChip)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarising conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71575 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (RNA-Seq)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarizing conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71645 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human Th17 cell differentiation
The study aims at identifying transcriptional changes induced by in vitro polarization of human cord blood CD4+ cells towards Th17 subtype with combination of IL6, IL1b and TGFb by using timeseries data. In this study, we identified gene expression changes characterizing early stages of human Th17 c...
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-35103 | biostudies-arrayexpress
TranscriptomicsComparative analysis of human and mouse transcriptomes of Th17 cell priming.
Uncontrolled Th17 cell activity is associated with cancer and autoimmune and inflammatory diseases. To validate the potential relevance of mouse models of targeting the Th17 pathway in human diseases we used RNA sequencing to compare the expression of coding and non-coding transcripts during the pri...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-52260 | biostudies-arrayexpress
UnknownEvaluation of Yograj Guggulu, Ashwagandha Churna and Narayana Taila in management of Osteoarthritis Knee: A study in tribal dominant community.
Not available
S-EPMC12023793 | biostudies-literature
GenomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (ChIP-Seq)
For the purpose of the Gene Regulatory Network validation we have performed chromatin-immunoprecipitation sequencing (ChIP-Seq) experiment for three transcription factors; namely GATA3, MAF and MYB. ChIP-Seq of GATA3, MAF and MYB in human naïve CD4+ T-cells differentiated toward Th1 and Th2 until d...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-72266 | biostudies-arrayexpress
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